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Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules

  • Yu Zhou (a1), Qilong Zhao (a1) (a2), Natasha L.Y. Tsai (a1) and Min Wang (a1)

Abstract

Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic investigation into the dual release of anticancer drugs and biomacromolecules from the bicomponent nanofibrous scaffolds is performed. Their release behavior is affected by different fabrication techniques and different polymers used. We show that the bicomponent scaffold fabricated by dual-source dual-power emulsion electrospinning enables dual release of anticancer drugs and biomacromolecules in a controlled manner, holding promise for combinational cancer postoperative care.

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Corresponding author

Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at ql.zhao@siat.ac, memwang@hku.hk

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MRS Communications
  • ISSN: 2159-6859
  • EISSN: 2159-6867
  • URL: /core/journals/mrs-communications
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