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Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules

Published online by Cambridge University Press:  04 March 2019

Yu Zhou ,
Qilong Zhao Open the ORCID record for Qilong Zhao [Opens in a new window] ,
Natasha L.Y. Tsai  and
Min Wang
Yu Zhou
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Qilong Zhao*
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China
Natasha L.Y. Tsai
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Min Wang*
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
*
Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at ql.zhao@siat.ac, memwang@hku.hk
Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at ql.zhao@siat.ac, memwang@hku.hk
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Abstract

Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic investigation into the dual release of anticancer drugs and biomacromolecules from the bicomponent nanofibrous scaffolds is performed. Their release behavior is affected by different fabrication techniques and different polymers used. We show that the bicomponent scaffold fabricated by dual-source dual-power emulsion electrospinning enables dual release of anticancer drugs and biomacromolecules in a controlled manner, holding promise for combinational cancer postoperative care.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 1 , March 2019 , pp. 413 - 420
Copyright
Copyright © Materials Research Society 2019 

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References

1.Griffith, L.G. and Naughton, G.: Tissue engineering—current challenges and expanding opportunities. Science 295, 1009 (2002).Google Scholar
2.Webber, M.J., Khan, O.F., Sydlik, S.A., Tang, B.C., and Langer, R.: A perspective on the clinical translation of scaffolds for tissue engineering. Ann. Biomed. Eng. 43, 641 (2015).Google Scholar
3.Stevens, M.M. and George, J.H.: Exploring and engineering the cell surface interface. Science 310, 1135 (2005).Google Scholar
4.Jiang, T., Carbone, E.J., Lo, K.W.H., and Laurencin, C.T.: Electrospinning of polymer nanofibers for tissue regeneration. Prog. Polym. Sci. 46, 1 (2015).Google Scholar
5.Dahlin, R.L., Kasper, F.K., and Mikos, A.G.: Polymeric nanofibers in tissue engineering. Tissue Eng., Part B 17, 349 (2011).Google Scholar
6.Peng, S., Jin, G., Li, L., Li, K., Srinivasan, M., Ramakrishna, S., and Chen, J.: Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment. Chem. Soc. Rev. 45, 1225 (2016).Google Scholar
7.Zhao, Q. and Wang, M.: Chapter 20-smart multifunctional tissue engineering scaffolds. In Smart Materials for Tissue Engineering: Applications, Wang, Q., ed, UK-Cambridge: Royal Society of Chemistry, 2017; p. 558.Google Scholar
8.Xu, X., Chen, X., Ma, P., Wang, X., and Jing, X.: The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur. J. Pharm. Biopharm. 70, 165 (2008).Google Scholar
9.Zhao, Q., Lu, W.W., and Wang, M.: Modulating the release of vascular endothelial growth factor by negative-voltage emulsion electrospinning for improved vascular regeneration. Mater. Lett. 193, 1 (2017).Google Scholar
10.Wei, J., Hu, J., Li, M., Chen, Y., and Chen, Y.: Multiple drug-loaded electrospun PLGA/gelatin composite nanofibers encapsulated with mesoporous ZnO nanospheres for potential postsurgical cancer treatment. RSC Adv. 4, 28011 (2014).Google Scholar
11.Jassal, M., Sengupta, S., and Bhowmick, S.: Functionalization of electrospun poly (caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride. J. Biomater. Sci., Polym. Ed. 26, 1425 (2015).Google Scholar
12.Tiwari, A.P., Hwang, T.I., Oh, J.M., Maharjan, B., Chun, S., Kim, B.S., Joshi, M.K., Park, C.H., and Kim, C.S.: pH/NIR-responsive polypyrrole functionalized fibrous localized drug delivery platform for synergistic cancer therapy. ACS Appl. Mater. Interfaces 10, 20256 (2018).Google Scholar
13.Li, X., Su, Y., Liu, S., Tan, L., Mo, X., and Ramakrishna, S.: Encapsulation of proteins in poly (l-lactide-co-caprolactone) fibers by emulsion electrospinning. Colloids Surf., B 75, 418 (2010).Google Scholar
14.Nair, L.S. and Laurencin, C.T.: Biodegradable polymers as biomaterials. Prog. Polym. Sci. 32, 762 (2007).Google Scholar
15.Wang, C. and Wang, M.: Electrospun multicomponent and multifunctional nanofibrous bone tissue engineering scaffolds. J. Mater. Chem. B 5, 1388 (2017).Google Scholar
16.Wang, C., Wang, L., and Wang, M.: Evolution of core–shell structure: from emulsions to ultrafine emulsion electrospun fibers. Mater. Lett. 124, 192 (2014).Google Scholar
17.Fridrikh, S.V., Yu, J.H., Brenner, M.P., and Rutledge, G.C.: Controlling the fiber diameter during electrospinning. Phys. Rev. Lett. 90, 144502 (2003).Google Scholar
18.Cui, W.G., Li, X.H., Zhou, S.B., and Weng, J.: Degradation patterns and surface wettability of electrospun fibrous mats. Polym. Degrad. Stab. 93, 731 (2008).Google Scholar
19.Szentivanyi, A., Chakradeo, T., Zernetsch, H., and Glasmacher, B.: Electrospun cellular microenvironments: understanding controlled release and scaffold structure. Adv. Drug Delivery Rev. 63, 209 (2011).Google Scholar
20.Versypt, A.N.F., Pack, D.W., and Braatz, R.D.: Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres—a review. J. Control. Release 165, 29 (2013).Google Scholar
21.Chakraborty, S., Liao, I.C., Adler, A., and Leong, K.W.: Electrohydrodynamics: a facile technique to fabricate drug delivery systems. Adv. Drug Delivery Rev. 61, 1043 (2009).Google Scholar
22.Allen, T.M. and Cullis, P.R.: Drug delivery systems: entering the mainstream. Science 303, 1818 (2004).Google Scholar
23.Reed, S. and Wu, B.: Sustained growth factor delivery in tissue engineering applications. Ann. Biomed. Eng. 42, 1528 (2014).Google Scholar
24.Biondi, M., Ungaro, F., Quaglia, F., and Netti, P.A.: Controlled drug delivery in tissue engineering. Adv. Drug Delivery Rev. 60, 229 (2008).Google Scholar