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3D Printed porous tissue engineering scaffolds with the self-folding ability and controlled release of growth factor

Published online by Cambridge University Press:  04 September 2020

Jiahui Lai ,
Junzhi Li  and
Min Wang
Jiahui Lai
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Junzhi Li
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
Min Wang*
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong
*
Address all correspondence to Min Wang at memwang@hku.hk
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Abstract

This study investigated a new strategy for fabricating porous scaffolds with the self-folding ability and controlled release of growth factors (GFs) via 3D printing. The scaffolds were a bilayer structure comprising a poly(D,L-lactide-co-trimethylene carbonate) scaffold for providing the shape morphing ability and a gelatin methacrylate scaffold for encapsulating and delivering GF. The structure, shape morphing behavior, GF release, and its effect on stem cell behavior were studied for new scaffolds. The results suggest that these scaffolds have great potential for regenerating tissues such as blood vessels. This work also contributes to developments of 3D printing in tissue engineering.

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 4 , December 2020 , pp. 579 - 586
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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