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New Directions in Photopolymerizable Biomaterials

Published online by Cambridge University Press:  31 January 2011

Kristi S. Anseth  and
Jason A. Burdick
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Abstract

This article is based on the Outstanding Young Investigator Award presentation given by Kristi S. Anseth at the 2001 MRS Spring Meeting on April 17, 2001, in San Francisco. Anseth was recognized for “innovative work in polymeric biomaterials for drug delivery, bone and cartilage repair, and tissue engineering, and for outstanding leadership potential in this interdisciplinary field of materials research.”

Photopolymerization provides many advantages as a technique for the fabrication of biomaterials. Temporal and spatial control, along with the diversity in material properties found with photopolymerizable materials, are advantageous in the biomaterials industry. For instance, multifunctional anhydride monomers form highly cross-linked surface-eroding networks directly in bone defects. These networks have good mechanical properties that are maintained with degradation and have the potential to restore tissue-like properties to bone during the healing process. Additionally, cartilage-forming cells photoencapsulated in hydrogel networks secrete an extracellular matrix as the hydrogel is resorbed and may provide a treatment alternative for cartilage defects that do not heal spontaneously. Finally, transdermal polymerization (photopolymerization through the skin) of multifunctional monomers is a noninvasive technique that is being developed for tissue regeneration and wound-healing applications.

Keywords

biodegradationphotopolymerizationtissue engineering.
Type
Research Article
Information
MRS Bulletin , Volume 27 , Issue 2: Science and Technology of Shape-Memory Alloys: New Developments , February 2002 , pp. 130 - 136
Copyright
Copyright © Materials Research Society 2002

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