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Making Lipid Membranes Rough, Tough, and Ready to Hit the Road

Published online by Cambridge University Press:  31 January 2011

Susan Daniel ,
Fernando Albertorio  and
Paul S. Cremer
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Abstract

Solid-supported lipid bilayers hold strong promise as bioanalytical sensor platforms because they readily mimic the same multivalent ligand-receptor interactions that occur in real cells. Such devices might be used to monitor air and water quality under real-world conditions. At present, however, supported membranes are considered too fragile to survive the harsh environments typically required for non-laboratory use. Specifically, they lack the resiliency to withstand air exposure and the thermal and mechanical stresses associated with device transport, storage, and continuous use over long periods of time. Several successful strategies are now emerging to make supported membranes tougher. These strategies incorporate mimics of the cytoskeleton and glycocalyx of real cell membranes. The promise of these more robust lipid bilayer architectures indicates that future materials should be designed to more fully resemble the actual structure of cell membranes.

Keywords

biologicalbiomimeticcellularsensor.
Type
Research Article
Information
MRS Bulletin , Volume 31 , Issue 7: Materials Science of Supported Lipid Membranes , July 2006 , pp. 536 - 540
Copyright
Copyright © Materials Research Society 2006

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