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Collagen and Hydroxyapatite Composite Membranes as Drug-Carrying Support for Biomedical Applications

Published online by Cambridge University Press:  24 January 2017

Daichi Kajiwara  and
Toshiyuki Ikoma
Daichi Kajiwara*
Affiliation:
Department of Material Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
Toshiyuki Ikoma
Affiliation:
Department of Material Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan
*
*(Email: kajiwara.d.aa@m.titech.ac.jp)
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Abstract

Medical products comprised of devices and drugs have been known as a combination product. The biodegradable collagen (Col) sponges impregnated with recombinant human bone morphogenetic protein can make bone formation hasten. It is expected further features by a combination of various growth factors and artificial bone materials. The binding properties of such factors to Col and hydroxyapatite (HAp) have not been elucidate to achieve a controlled release. In this study, we investigated artificial periosteum-like membranes made from tilapia fish Col and HAp composites as a drug carrying support. The Col-HAp composites with three different compositions in weight ratio of 2:8, 5:5 and 8:2 were made and crosslinked by irradiation of gamma-ray in wet condition. The tensile strengths of the membranes in wet or dry were depended on the compositions; however the strengths of the membranes in wet were apparently weaker at 1/10 or less than those in dry at a maximum 90 MPa. The adsorption ability of proteins, bovine serum albumin (BSA) or lysozyme (LSZ), on the membranes exhibited different tendency; the membranes including higher weight ratio of HAp adsorbed BSA rather than LSZ. These results indicated that the artificial Col-HAp membranes would be the suitable materials for biomedical device as combination products.

Keywords

compositebiomaterialadsorption
Type
Articles
Information
MRS Advances , Volume 2 , Issue 19-20: Biomaterials and Soft Materials , 2017 , pp. 1083 - 1088
Copyright
Copyright © Materials Research Society 2017 

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