Light microscopy has many advantages and several disadvantages. One of the advantages is that different wavelengths are perceived as different colors, and with the proper use of dyes, filters, etc. several different structures can be imaged in the same object. One the major disadvantages is that the resolution is limited by the wavelength, a limit known as the diffraction barrier. Several recently-developed techniques have allowed light microscopy to “break” the diffraction barrier, a phenomenon known as “super-resolution.” Lothar Schermelleh, Peter Carlton, Sebastian Haase, Lin Shao, Lukman Winoto, Peter Kner, Brian Burke, Cristina Cardoso, David Agard, Mats Gustafsson, Heinhrich Leonardt, and John Sedat have created a new microscope that not only achieves super-resolution, but creates images in 3 dimensions and multiple colors. Not only that, but preparing specimens to examine with this microscope uses conventional methods, and they claim the microscope is easy to use!