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Superoxide Dismutase Detection in Human Cumulus Oophorus Cells

Published online by Cambridge University Press:  03 October 2008

L. Matos ,
D. Stevenson ,
F. Gomes ,
J.L. Silva-Carvalho  and
H. Almeida
L. Matos
Affiliation:
Laboratório de Biologia Celular e Molecular, Faculdade de Medicina, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, andIBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
D. Stevenson
Affiliation:
Unit of Reproductive Medicine, Department of Gynaecology and Obstetrics, Faculdade de Medicina do Porto/Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
F. Gomes
Affiliation:
Unit of Reproductive Medicine, Department of Gynaecology and Obstetrics, Faculdade de Medicina do Porto/Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
J.L. Silva-Carvalho
Affiliation:
Unit of Reproductive Medicine, Department of Gynaecology and Obstetrics, Faculdade de Medicina do Porto/Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
H. Almeida*
Affiliation:
Laboratório de Biologia Celular e Molecular, Faculdade de Medicina, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, andIBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal
*
Corresponding author. E-mail: almeidah@med.up.pt

Abstract

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A key factor limiting the success of Assisted Reproduction Techniques (ART) is oocyte and embryo quality, usually assessed by their morphologic appearance. Due to the subjectivity and inaccuracy of such criteria, other predictors of oocyte and embryo quality would be welcome. Cumulus oophorus (c.o.) cells are eligible as oocyte quality predictors, due to their direct contact with it. In addition, ART success was also related to oxidative stress, whose effects in the porcine and bovine oocytes may be prevented by the presence of c.o. cells. Yet, it is unknown if a similar effect exists in humans due to the scarcity of studies employing human c.o. cells.

Type
Abstract
Information
Microscopy and Microanalysis , Volume 14 , Supplement S3 , September 2008 , pp. 99 - 100
Copyright
Copyright © Microscopy Society of America 2008