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Strategies For Immunodissection Of The Connective Tissue Matrix And Basement Membranes

Published online by Cambridge University Press:  02 July 2020

Douglas R. Keene  and
Sara F. Tufa
Douglas R. Keene
Affiliation:
Research Unit, Shriners Hospital for Children, Portland, Oregon97201
Sara F. Tufa
Affiliation:
Research Unit, Shriners Hospital for Children, Portland, Oregon97201
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Extract

Connective tissue matrices are quite diversified and include that composing skin, tendon, bone, cartilage, cornea and many others. The main component of the connective tissue matrix is collagen, composing approximately 70% of the dry weight of the human body. More members of the collagen family are discovered each year, with over twenty types described to date. Many of these collagens are tissue specific. In addition to the collagens, the connective tissue matrix is also the residence of epithelial and endothelial basement membranes and many other molecules including a variety of proteoglycans and elastic fiber components. The cells within the matrix are highly differentiated and task specific.

Using immunocytochemical technique applied at the level of the electron microscope, we have focused our resources to understand the structure and functional role of these matrix molecules.

Type
Highlights Of Biological Microscopy In The Pacific Northwest Usa
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1222 - 1223
Copyright
Copyright © Microscopy Society of America

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References

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7) This work was supported by the Shriners Hospital for ChildrenGoogle Scholar