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Pulmonary Neuroepithelial Bodies in Neonatal Rats Chronically Exposed to Nitric Oxide

Published online by Cambridge University Press:  02 July 2020

Kuen-Shan Hung  and
Xay K. Her
Kuen-Shan Hung
Affiliation:
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS66160-7400
Xay K. Her
Affiliation:
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS66160-7400
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Extract

Pulmonary neuroepithelial bodies (NEBs) consist of clusters of innervated endocrine cells localized in human and animal lungs. They are prominent in late fetal and neonatal lungs and their density declines with increased postnatal age. Gas sensing functions of these structures have been suggested by Lauweryns and Cokelaere. Subsequent experiments show that chronic hypoxia leads to an increase in the size or number of NEBs, and prolonged hyperoxia also causes elevation of NEB numbers. Animals exposed to cigarette smoke also had an increased number of immunoreactive NEBs.

Inhaled nitric oxide (NO) can reverse pulmonary vasoconstriction induced by hypoxic breathing or ligation of ductus arteriosus in newborn and young animals. These studies led to clinical use of NO for treatment of pediatric patients with pulmonary hypertension. However, direct effects of inhaled NO on various components of the lung are not clearly understood.

Type
Biological Structure (Cells, Tissues, Organ Systems)
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 880 - 881
Copyright
Copyright © Microscopy Society of America

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References

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