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Morphological Characterization of a Sustained-Release Drug Implant by Scanning Electron Microscopy, Polarized Light Microscopy and Image Analysis

Published online by Cambridge University Press:  02 July 2020

J.P. Neilly ,
J.S. Deng ,
J.L. House  and
J.A. Fagerland
J.P. Neilly
Affiliation:
Department of Microscopy and Microanalysis, Abbott Laboratories, Abbott Park, IL60064
J.S. Deng
Affiliation:
Department of Advanced Drug Delivery, Abbott Laboratories, Abbott Park, IL60064
J.L. House
Affiliation:
Department of Microscopy and Microanalysis, Abbott Laboratories, Abbott Park, IL60064
J.A. Fagerland
Affiliation:
Department of Microscopy and Microanalysis, Abbott Laboratories, Abbott Park, IL60064
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Extract

Septacin is a sustained-release antibiotic currently under development by the Hospital Products Division of Abbott Laboratories. The product is designed to be used as an anti-infective implant in orthopedic surgical procedures with a sustained drug release for up to six weeks in vivo. It consists of gentamicin sulfate formulated with a bioerodable polyanhydride copolymer. The polymer is biodegradable and has been approved by the FDA for human clinical trials. The final product is obtained by mixing 20% gentamicin sulfate with molten polymer and injection molding it to form cylindrical Septacin beads.

The microstructure of drug particles and polymer matrix is critical to the performance of sustained release products, thus scanning electron microscopy (SEM) and polarized light microscopy (PLM) were utilized in this study. SEM has proven useful for evaluating the microstructure of drug formulations3 and was used to examine the drug-polymer matrix structure. Average drug particle size and distribution were determined, and the drug-polymer boundary was evaluated.

Type
Biomaterials
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 932 - 933
Copyright
Copyright © Microscopy Society of America

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References

References:

1.Shieh, L. et al., J. Biomed. Mater. Res. 28 (1994) 1465–1475.CrossRefGoogle Scholar
2.Tamada, J. and Langer, R., J. Biomat. Sci. Polymer Educ. 3 (1992) 315–353.CrossRefGoogle Scholar
3.Neilly, J.P. and Miller, M.F., Proc. Ann. MSA Meeting 49 (1991) 518.Google Scholar