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In Vitro Investigation of the Synthetic Sebum Adsorbing Efficacy of Acrylate Copolymer as an Excipient And In Clinac ™ Oc

Published online by Cambridge University Press:  02 July 2020

R. W. Taylor ,
Christine Smith  and
M. White
R. W. Taylor
Affiliation:
Department of Biology, Morris Brown College, Atlanta, Georgia30314
Christine Smith
Affiliation:
Department of Biology, Morris Brown College, Atlanta, Georgia30314
M. White
Affiliation:
Ferndale Laboratories, Inc. Ferndale, Michigan48220
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Extract

While sebum provides several functions in the integument, there is considerable interest in the control of excess sebum on the human skin. The primary function of sebum is to lubricate and waterproof the stratum cornenum layer, in addition to preventing hair from becoming brittle. In several cases, the secretion of sebum is inhibited as a result of blockage of the drainage pathway for the sebaceous glands which may result in abnormal skin conduction (1,2). Clinac™ OC (Oil Control) has been developed with a special oil adsorbing polymer, DVB/lsobornyl Methacrylate/Lautyl Methacrylate Copolymer (3). This particular copolymer posses the capacity to adsorb oils because of its high affinity for hydrophobic nonpolar substances. The purpose of this investigation is to show the adsorptive capacity of the acrylate copolymer in Clinac™ OC preparation and in buffer.

The acrylate polymer was incubated in artificial sebum for 4 hrs and 8 hrs at 37 C.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1180 - 1181
Copyright
Copyright © Microscopy Society of America

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References

1. Nordstrom, K. M . et. al. J Invest Dermatol, 86:700–705 (1986)CrossRefGoogle Scholar

2. Webester, G.F., International J Dermatol, 28:313–317(1990)CrossRefGoogle Scholar

3. Cosmetic Ingredient Review (CIR), Wash, D.C.1–52 (1996)Google Scholar