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The Impact of Estrogen Depletion and Drug Treatment on Type I Collagen Microstructure

Published online by Cambridge University Press:  27 August 2014

Meagan Cauble
Affiliation:
Departments of Chemistry
Edward Rothman
Affiliation:
Statistics Center for Statistical Consultation and Research (CSCAR)
Kathleen Welch
Affiliation:
Center for Statistical Consultation and Research (CSCAR)
Ming Fang
Affiliation:
Departments of Chemistry
Le T. Duong
Affiliation:
University of Michigan, Ann Arbor, MI 48109. Bone Biology Group,Merck Research Laboratories, West Point, PA
Brenda L. Pennypacker
Affiliation:
University of Michigan, Ann Arbor, MI 48109. Bone Biology Group,Merck Research Laboratories, West Point, PA
Bradford G. Orr
Affiliation:
Physics
Mark M Banaszak Holl
Affiliation:
Departments of Chemistry Biomedical Engineering

Abstract

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Type
Abstract
Copyright
Copyright © Microscopy Society of America 2014 

References

1. Burr, D.B. The contribution of the organic matrix to bone’s material properties. Bone 31, 8-11 (2002).Google Scholar
2. Erickson, B., Fang, M., Wallace, J.M., Orr, B.G., Les, C.M., Banaszak Holl, M.M. Nanoscale structure of type I collagen fibrils: Quantitative measurement of D-spacing. Biotechnology Journal 8, 117-126 (2013).Google Scholar
3. Pennypacker, B.L., Duong, L.T., Cusick, T.E., Masarachia, P.J., Gentile, M.A., Gauthier, J.Y., Black, W.C., Scott, B.B., Samadfam, R., Smith, S.Y., Kimmel, D.B. Cathepsin K Inhibitors Prevent Bone Loss in Estrogen-Deficient Rabbits. Journal of Bone and Mineral Research 26, 252-262 (2011).Google Scholar
4. The authors acknowledge funding from Merck, Inc for support of this work.Google Scholar