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High-Resolution Ex Vivo Tissue Clearing, Lightsheet Imaging, and Data Analysis to Support Macromolecular Drug and Biomarker Distribution in Whole Organs and Tumors

Published online by Cambridge University Press:  22 July 2022

Niyanta Kumar ,
Petr Hrobař ,
Martin Vagenknecht ,
Jindrich Soukup ,
Peter Bloomingdale ,
Tomoko Freshwater ,
Sophia Bardehle ,
Roman Peter ,
Nadia Patterson  and
Ruban Mangadu
...Show all authors
Niyanta Kumar*
Affiliation:
ADME & Discovery Toxicology, Merck & Co. Inc., West Point, PA, United States
Petr Hrobař
Affiliation:
Data Science & Scientific Informatics, MSD, Prague, Czech Republic
Martin Vagenknecht
Affiliation:
Data Science & Scientific Informatics, MSD, Prague, Czech Republic
Jindrich Soukup
Affiliation:
Data Science & Scientific Informatics, MSD, Prague, Czech Republic
Peter Bloomingdale
Affiliation:
Quantitative Pharmacology and Pharmacometrics, Merck & Co. Inc., Boston, MA, United States
Tomoko Freshwater
Affiliation:
Quantitative Pharmacology and Pharmacometrics, Merck & Co. Inc., Rahway, NJ, United States
Sophia Bardehle
Affiliation:
Neuroscience, Merck & Co. Inc., Boston, MA, United States
Roman Peter
Affiliation:
Data Science & Scientific Informatics, MSD, Prague, Czech Republic
Nadia Patterson
Affiliation:
ADME & Discovery Toxicology, Merck & Co. Inc., West Point, PA, United States
Ruban Mangadu
Affiliation:
Immuno-Oncology, Merck & Co. Inc., San Francisco, CA, United States
Cinthia Pastuskovas
Affiliation:
ADME & Discovery Toxicology, Merck & Co. Inc., San Francisco, CA, United States
Mark Cancilla
Affiliation:
ADME & Discovery Toxicology, Merck & Co. Inc., West Point, PA, United States
*
*Corresponding author: niyanta.kumar@merck.com

Abstract

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Type
Imaging, Microscopy, and Micro/Nano-Analysis of Pharmaceutical, Biopharmaceutical, and Medical Health Products - Research, Development, Analysis, Regulation, and Commercialization
Information
Microscopy and Microanalysis , Volume 28 , Supplement S1 , August 2022 , pp. 1436 - 1437
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Copyright
Copyright © Microscopy Society of America 2022

References

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