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Expansion Pathology: Nanoscale Imaging of Clinical Specimens with Optical Microscopy

Published online by Cambridge University Press:  30 July 2021

Yongxin Zhao ,
Feifei Fu  and
Octavian Bucur
Yongxin Zhao
Affiliation:
Carnegie Mellon University, Pittsburgh, Pennsylvania, United States
Feifei Fu
Affiliation:
Carnegie Mellon University, Pittsburgh, Pennsylvania, United States
Octavian Bucur
Affiliation:
QPathology, Boston, Massachusetts, United States

Abstract

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Type
Challenges and Advances in Electron Microscopy Research and Diagnosis of Diseases in Humans, Plants and Animals (FIG associated)
Information
Microscopy and Microanalysis , Volume 27 , Supplement S1 , August 2021 , pp. 1902 - 1903
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Chen, F.; Tillberg, P. W.; Boyden, E. S. Expansion Microscopy. Science 2015, 347 (6221), 543–548. https://doi.org/10.1126/science.1260088.Google ScholarPubMed
Wassie, A. T.; Zhao, Y.; Boyden, E. S. Expansion Microscopy: Principles and Uses in Biological Research. Nat. Methods 2019, 16 (1), 33–41. https://doi.org/10.1038/s41592-018-0219-4.CrossRefGoogle ScholarPubMed
Zhao, Y.; Bucur, O.; Irshad, H.; Chen, F.; Weins, A.; Stancu, A. L.; Oh, E.-Y. Y.; Distasio, M.; Torous, V.; Glass, B.; Stillman, I. E.; Schnitt, S. J.; Beck, A. H.; Boyden, E. S. Nanoscale Imaging of Clinical Specimens Using Pathology-Optimized Expansion Microscopy. Nat Biotech 2017, 35 (8), 757–764. https://doi.org/10.1038/nbt.3892.CrossRefGoogle ScholarPubMed
Klimas, A.; Bucur, O.; Njeri, B.; Zhao, Y. Nanoscopic Imaging of Human Tissue Sections via Physical and Isotropic Expansion. JoVE 2019, No. 151, e60195. https://doi.org/doi:10.3791/60195.Google Scholar
Bucur, O.; Fu, F.; Calderon, M.; Mylvaganam, G. H.; Ly, N. L.; Day, J.; Watkin, S.; Walker, B. D.; Boyden, E. S.; Zhao, Y. Nanoscale Imaging of Clinical Specimens Using Conventional and Rapid-Expansion Pathology. Nat. Protoc. 2020, 15 (5), 1649–1672. https://doi.org/10.1038/s41596-020-0300-1.CrossRefGoogle ScholarPubMed