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Investigation on the Dependency of Phase Retrieval Accuracy Versus Edge Enhancement to the Noise Ratio of X-ray Propagation-Based Phase-Contrast Imaging

Published online by Cambridge University Press:  13 August 2019

Lin Zhang
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China
Huijuan Zhao
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, People's Republic of China
Jingying Jiang*
Affiliation:
Beijing Advanced Innovation Centre for Big Data-based Precision Medicine, Beihang University, Beijing 100191, China
Limin Zhang
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, People's Republic of China
Jiao Li
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, People's Republic of China
Feng Gao
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, People's Republic of China
Zhongxing Zhou*
Affiliation:
School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, People's Republic of China Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, People's Republic of China Tianjin Shareshine Technology Development Co, Ltd., Tianjin, People's Republic of China Tianjin Key Laboratory in Environmental Monitoring Techniques, Tianjin, People's Republic of China
*
*Author for correspondence: Zhongxing Zhou, E-mail: zhouzhongxing@tju.edu.cn; Jingying Jiang, E-mail: jingyingjiang@buua.edu.cn
*Author for correspondence: Zhongxing Zhou, E-mail: zhouzhongxing@tju.edu.cn; Jingying Jiang, E-mail: jingyingjiang@buua.edu.cn
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Abstract

Phase retrieval is necessary for propagation-based phase-contrast imaging (PB-PCI). Arhatari established a model for predicting the impact of the sample-to-detector distance and the system noise on the phase retrieval performance. We have extended Arhatari's model to account for the parameters of excessive source size, finite detector resolution, and geometrical magnification for more practical cases. However, there exist interaction effects among these parameters resulting in difficulty of predicting the phase retrieval performance. In this study, we found that optimizing the trade-off among these parameters for phase retrieval is consistent with the improvement of edge enhancement to noise ratio (EE/N) in the “forward problem” of the PB-PCI. Hence, we engaged in establishing a relationship between EE/N and phase retrieval performance in terms of the “forward problem” and “inverse problem” of the PB-PCI, respectively. Our results showed that, at fixed detector resolution, phase retrieval from the phase-contrast projections at the same EE/N level resulted in the consistent phase retrieval performance. Therefore, the performance of phase retrieval can be predicted based on the EE/N level and be quantitatively optimized by increasing EE/N.

Type
Biological Applications
Copyright
Copyright © Microscopy Society of America 2019 

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