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Autowaves in the Model of Infiltrative Tumour Growth with Migration-Proliferation Dichotomy

Published online by Cambridge University Press:  15 June 2011

A.V. Kolobov ,
V.V. Gubernov  and
A.A. Polezhaev
A.V. Kolobov
Affiliation:
Department of Theoretical Physics, P.N. Lebedev Physical Institute, Leninskij prosp. 53, Moscow 119991, Russia
V.V. Gubernov
Affiliation:
Department of Theoretical Physics, P.N. Lebedev Physical Institute, Leninskij prosp. 53, Moscow 119991, Russia
A.A. Polezhaev*
Affiliation:
Department of Theoretical Physics, P.N. Lebedev Physical Institute, Leninskij prosp. 53, Moscow 119991, Russia
*
⋆Corresponding author. E-mail: apol@lpi.ru
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Abstract

A mathematical model of infiltrative tumour growth is investigated taking into account transitions between two possible states of malignant cells: proliferation and migration. These transitions are considered to depend on oxygen level in a threshold manner where high oxygen concentration allows cell proliferation, while concentration below a certain critical value induces cell migration. The infiltrative tumour spreading rate dependence on model parameters is obtained. It is shown that the tumour growth rate depends on the tissue oxygen level in a threshold manner.

Keywords

tumor growthproliferation and migration dichotomyoxygen
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 6 , Issue 7: Mathematical modeling in biomedical applications , 2011 , pp. 27 - 38
Copyright
© EDP Sciences, 2011

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