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Tumour control probability of a UK cohort of lung SABR patients

Published online by Cambridge University Press:  21 October 2020

J. E. Marsden Open the ORCID record for J. E. Marsden [Opens in a new window]
J. E. Marsden*
Affiliation:
Radiotherapy Physics, Queen’s Centre, Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Hull, East Yorkshire, HU16 5JQ, UK
*
Author for correspondence: Jenny Marsden, Radiotherapy Physics, Queen’s Centre, Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Hull, East Yorkshire, HU16 5JQ, UK. Tel: 01482 461384. E-mail: Jenny.Marsden@hey.nhs.uk
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Abstract

Aims:

The aim of this work is to report on the tumour control probability (TCP) of a UK cohort of lung stereotactic ablative radiotherapy patients (n = 198) for a range of dose and fractionations common in the UK.

Materials and methods:

TCP values for 3 (54 Gy), 5 (55 and 60 Gy) and 8 (50 Gy) fraction (#) schemes were calculated with the linear-quadratic Marsden TCP model using the Biosuite software.

Results:

TCP values of 100% were computed for the 3 # and for 5 # (α/β = 10 Gy) cohorts; reduced to 99% (range 97–100) for the 5 # cohort only when an α/β of 20 Gy was used. The average TCP value for the 50 Gy in 8 # regime was 97% (range 92–99, α/β = 10 Gy) and 64% (range 48–79, α/β = 20 Gy). Statistical significant differences were observed between the α/β of 10 Gy versus 20 Gy groups and between all data grouped by fraction.

Conclusion:

TCPs achievable with current planning techniques in the UK have been presented. The ultra-conservative 50 Gy in 8 # scheme returns a significantly lower TCP than the other regimes.

Keywords

lung SABRradiobiologytumour control probability
Type
Technical Note
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 2 , June 2022 , pp. 297 - 299
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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