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Stereotactic radiosurgery for patients with newly diagnosed glioblastoma multiforme (GBM): comparison with intra-operative radiotherapy and evaluation of prognostic factors

Published online by Cambridge University Press:  01 September 2007

Masayuki Matsuo ,
Jun Shinoda ,
Kazuhiro Miwa ,
Hirohito Yano ,
Toru Iwama ,
Shinya Hayashi ,
Sunaho Okada ,
Osamu Tanaka  and
Hiroaki Hoshi
Masayuki Matsuo*
Affiliation:
Department of Radiation Oncology Gifu, Japan
Jun Shinoda
Affiliation:
Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Department of Neurosurgery, Kizawa Memorial Hospital, Minokamo, Japan Gifu, Japan
Kazuhiro Miwa
Affiliation:
Chubu Medical Centre for Prolonged Traumatic Brain Dysfunction, Department of Neurosurgery, Kizawa Memorial Hospital, Minokamo, Japan Gifu, Japan
Hirohito Yano
Affiliation:
Department of Neurosurgery, Gifu, Japan
Toru Iwama
Affiliation:
Department of Neurosurgery, Gifu, Japan
Shinya Hayashi
Affiliation:
Department of Radiology, Gifu University School of Medicine, Gifu, Japan
Sunaho Okada
Affiliation:
Department of Radiology, Gifu University School of Medicine, Gifu, Japan
Osamu Tanaka
Affiliation:
Department of Radiology, Gifu University School of Medicine, Gifu, Japan
Hiroaki Hoshi
Affiliation:
Department of Radiology, Gifu University School of Medicine, Gifu, Japan
*
Correspondence to: Masayuki Matsuo, Department of Radiation Oncology, Kizawa Memorial Hospital, 590 Shimokobi, Minokamo 505-8503, Japan. E-mail: matsuo@kizawa-memorial-hospital.jp
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Abstract

The goals of this study were (1) to compare, in a single institute, the clinical results of patients with newly diagnosed glioblastoma multiforme (GBM) treated with stereotactic radiosurgery (SRS), which has been incorporated into the initial management approach, with those in-patients treated with intra-operative radiotherapy (IORT) and (2) to assess whether these local irradiation boost therapies are prognostic factors on survival analysis. One hundred and twenty adult patients with supratentorial GBM had undergone tumour resection or biopsy and had received external beam radiotherapy (EBRT). Of them, 31 underwent IORT, 29 underwent SRS, and the remaining 60 had no local high-dose irradiation boost. The local irradiation boost led to clearly better results on survival of GBM patients. Furthermore, SRS is less invasive and allows for meticulous target planning of the irradiation boost, and was superior to IORT in terms of survival prolongation as well as suppression of local tumour recurrence/progression at the primary site in this series. In addition, SRS was a significant, positive prognostic factor for survival as well as gross-total resection of the tumour, and could be an alternative therapeutic modality to IORT for GBM.

Keywords

Glioblastoma multiformeintra-operative radiotherapylocal recurrenceprognostic factorstereotactic radiosurgery
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 6 , Issue 3 , September 2007 , pp. 143 - 152
Copyright
Copyright © Cambridge University Press 2007

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