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Proton beam radiotherapy of locally advanced or recurrent conjunctival squamous cell carcinoma: experience of the CATANA Centre

Published online by Cambridge University Press:  09 November 2020

Roberto Milazzotto Open the ORCID record for Roberto Milazzotto [Opens in a new window] ,
Rocco Luca Emanuele Liardo ,
Giuseppe Privitera ,
Luigi Raffaele ,
Vincenzo Salamone ,
Floriana Arena ,
Stefano Pergolizzi ,
Giacomo Cuttone ,
Giuseppe A. P. Cirrone  and
Andrea Russo
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Roberto Milazzotto*
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Rocco Luca Emanuele Liardo
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Giuseppe Privitera
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Luigi Raffaele
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Vincenzo Salamone
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy
Floriana Arena
Affiliation:
Department of Radiotherapy, AOU Policlinico di Messina, Messina98125, Italy
Stefano Pergolizzi
Affiliation:
Department of Radiotherapy, AOU Policlinico di Messina, Messina98125, Italy Department of Scienze biomediche, odontoiatriche e delle immagini morfologiche e funzionali, University of Messina, Messina98125, Italy
Giacomo Cuttone
Affiliation:
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania95123, Italy
Giuseppe A. P. Cirrone
Affiliation:
National Institute for Nuclear Physics, Laboratori Nazionali del Sud, INFN-LNS, Catania95123, Italy
Andrea Russo
Affiliation:
Department of Ophthalmology, AOU Policlinico-VE di Catania, Catania95123, Italy
Teresio Avitabile
Affiliation:
Department of Ophthalmology, AOU Policlinico-VE di Catania, Catania95123, Italy
Pietro Valerio Foti
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Stefano Palmucci
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Antonio Basile
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
Corrado Spatola
Affiliation:
Department of Radiology and Radiotherapy, AOU Policlinico-VE di Catania, Catania95123, Italy Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia”, University of Catania, Catania95123, Italy
*
Author for correspondence: Dr Roberto Milazzotto, AOU Policlinico-VE di Catania, Via Santa Sofia 78, Catania95123, Italy. Tel: 0039-3493837901. Fax: 0039-0953781315. E-mail: robertomilazz@hotmail.it
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Abstract

Aim:

Conjunctival squamous cell carcinoma (SCC) is a rare tumour of the ocular region and microscopic radical surgical is difficult. There are no single guidelines for therapeutic management and the role of radiation therapy is not clearly defined although conventionally photon or electron beams are used. Proton beam radiotherapy (PBRT) is a new option for a conservative approach and allows good sparing of the organs at risk.

Materials and methods:

After surgical resection, we collected 15 cases treated at our institution with PBRT. The dose delivered was between 48 and 60 Gy relative biological effectiveness (RBE), with fractions of 12–15 Gy RBE.

Results:

After an average period of 48 months, the patients achieved excellent disease control (overall survival and disease-free survival: 86·6%), with minimal acute and late toxicity.

Findings:

In this work, we present our experience on the use of PBRT technique in SCC treatment. A larger sample of patients is needed to draw conclusions about the impact of this treatment on disease recurrence and overall survival.

Keywords

conjunctival squamous cell carcinomaSCCproton beam radiotherapyocular superficial squamous neoplasiaOSSN
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 1 , March 2022 , pp. 97 - 104
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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References

Sun, EC, Fears, TR, Goedert, JJ. Epidemiology of squamous cell conjunctival cancer. Cancer Epidemiol Biomarkers Prev 1997; 6: 73–77.Google ScholarPubMed
Yang, J, Foster, CS. Squamous cell carcinoma of the conjunctiva. Int Ophthalmol Clin 1997; 37: 73–85.10.1097/00004397-199703740-00007CrossRefGoogle ScholarPubMed
Lee, GA, Hirst, LW. Ocular surface squamous neoplasia. Surv Ophthalmol 1995; 39: 429–450.10.1016/S0039-6257(05)80054-2CrossRefGoogle ScholarPubMed
Erie, JC, Campbell, RJ, Liesegang, TJ. Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology 1986; 93: 176–183.10.1016/S0161-6420(86)33764-3CrossRefGoogle ScholarPubMed
Gichuhi, S, Sagoo, MS, Weiss, HA, Burton, MJ. Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health 2013; 18(12): 1424–1443.10.1111/tmi.12203CrossRefGoogle ScholarPubMed
Lee, GA, Hirst, LW. Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane. A 10-year survey. Arch Ophthalmol 1992; 110(4): 525–527.10.1001/archopht.1992.01080160103042CrossRefGoogle ScholarPubMed
Gichuhi, S, Sagoo, MS, Weiss, HA, Burton, MJ. Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health 2013; 18(12): 1424–1443.10.1111/tmi.12203CrossRefGoogle ScholarPubMed
Tabrizi, SN, McCurrach, FE, Drewe, RH, et al. Human papillomavirus in corneal and conjunctival carcinoma. Aust NZ J Ophthalmol 1997; 25: 211–215.10.1111/j.1442-9071.1997.tb01394.xCrossRefGoogle ScholarPubMed
McDonnell, JM, McDonnell, PI, Sun, YY. Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia. Invest Ophthalmol Vis Sci 1992; 33: 184–189.Google ScholarPubMed
Carreira, H, Coutinho, F, Carrilho, C, Lunet, N. HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis. Br J Cancer 2013; 109(7): 1981–1988.10.1038/bjc.2013.539CrossRefGoogle ScholarPubMed
Goedert, JJ, Cote, TR. Conjunctival malignant disease with AIDS in USA. Lancet. 1995; 346(8969): 257–258.10.1016/S0140-6736(95)91309-2CrossRefGoogle ScholarPubMed
Cicinelli, MV, Marchese, A, Bandello, F. et al. Clinical management of ocular surface squamous neoplasia: a review of the current evidence. Ophthalmol Ther 2018; 7: 247–262.10.1007/s40123-018-0140-zCrossRefGoogle ScholarPubMed
Tunc, M, Char, DH, Crawford, B, Miller, T. Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases. Br J Ophthalmol 1999; 83(1): 98–103.10.1136/bjo.83.1.98CrossRefGoogle ScholarPubMed
Waddell, KM, Downing, RG, Lucas, SB, Newton, R. Corneo-conjunctival carcinoma in Uganda. Eye (Lond) 2006; 20(8): 893–899.10.1038/sj.eye.6702043CrossRefGoogle ScholarPubMed
Ramonas, KM, Conway, RM, Daftari, IK et al. Successful treatment of intraocularly invasive conjunctival squamous cell carcinoma with proton beam therapy. Arch Ophthalmol 2006; 124(1): 126–128.10.1001/archopht.124.1.126CrossRefGoogle ScholarPubMed
El-Assal, KS, Salvi, SM, Rundle, PA et al. Treatment of invasive ocular surface squamous neoplasia with proton beam therapy. Eye (Lond). 2013; 27(10): 1223–1224.10.1038/eye.2013.149CrossRefGoogle ScholarPubMed
Belaïd, A, Nasr, C, Jmour, O et al. Post-operative radiotherapy of conjunctival malignancies: a series of 24 cases. Asian Pac J Cancer Biol, 2017; 2(1): 3–8.10.31557/apjcb.2017.2.1.3-8CrossRefGoogle Scholar
Caujolle, JP, Maschi, C, Chauvel, P, Herault, J, Gastaud, P. Surgery and additional protontherapy for treatment of invasive and recurrent squamous cell carcinomas: techniqueand preliminary results. J Fr Ophtalmol 2009; 32(10): 707–714.10.1016/j.jfo.2009.10.016CrossRefGoogle Scholar
Spatola, C, Privitera, G, Raffaele, L et al. Protontherapy of ocular tumors: 5 years experience at Italian CATANA Centre. Rivista Medica 2008; 14(1): 97–101.Google Scholar
Cirrone, GAP, Cuttone, G, Raffaele, L et al. Clinical and research activities at the CATANA facility of INFN-LNS: from the conventional hadrontherapy to the laser-driven approach. Front Oncol 2017; 7: 223.10.3389/fonc.2017.00223CrossRefGoogle Scholar
Tocco, A, Privitera, G, Raffaele, L et al. Porocarcinoma of the eyelid treated with proton beam radiotherapy: case report and literature review. Acta Med Mediterr, 2018, 34(34): 203.Google Scholar
Gichuhi, S, Sagoo, MS. Squamous cell carcinoma of the conjunctiva. Comm Eye Health J 2016; 29(95): 52–53.Google ScholarPubMed
Graue, GF, Tena, LB, Finger, PT. Electron beam radiation for conjunctival squamous carcinoma. Ophthal Plast Reconstr Surg 2011; 27: 277–281.10.1097/IOP.0b013e31820d872fCrossRefGoogle ScholarPubMed
Finger, PT. Radiation therapy for orbital tumors: concepts, current use, and ophthalmic radiation side effects. Surv Ophthalmol 2009; 54(5): 545–568.CrossRefGoogle ScholarPubMed
Spatola, C, Militello, C, Tocco, A et al. Intensity-modulated radiotherapy for relapsed malignant pleural mesothelioma. Fut Oncol 2016; 12(23s): 67–71.CrossRefGoogle ScholarPubMed
Spatola, C, Tocco, A, Milazzotto, R et al. Role, timing and technique of radiotherapy in pediatric pleuropulmonary synovial sarcoma. Fut Oncol 2016; 12(23s): 73–77.10.2217/fon-2016-0331CrossRefGoogle ScholarPubMed