No CrossRef data available.
Article contents
Predictors of early vaginal stenosis during pelvic radiotherapy for locally advanced cervix cancer: a study from a tertiary cancer centre in Eastern India
Published online by Cambridge University Press: 02 March 2015
Abstract
Aim
To explore possible predictors of early vaginal stenosis among patients with locally advanced cervix cancer on pelvic chemoradiation.
Patients and methods
A total of 232 patients with locally advanced cervix cancer, who received pelvic radiotherapy at our institute from November 2011 to October 2013, were prospectively studied. Possible predictors chosen were age, tumour stage, initial vaginal involvement, concomitant chemotherapy and development of vaginitis of Radio Therapy Oncology Group grade 2 or more during radiotherapy. Multiple logistic regression was carried out to assess predictors and the relative risk of predictors was calculated.
Results
Initial vaginal involvement and addition of concomitant chemotherapy are predictors of early vaginal stenosis in locally advanced cervix cancer patients on pelvic chemoradiation. Relative risk for early vaginal stenosis with vaginal involvement at presentation was 16·31, whereas that for concomitant chemotherapy was 9·95.
Conclusion
Among patients with locally advanced cervix cancer receiving pelvic chemoradiation, two factors, namely, initial vaginal involvement and concomitant chemotherapy are predictive of early vaginal stenosis. Patients with these factors should be assessed at regular intervals for early vaginal stenosis during pelvic chemoradiation to assess the optimal timing of intracavitary brachytherapy. This is particularly of importance in the absence of facilities for interstitial brachytherapy to ensure appropriate target coverage.
- Type
- Short Communication
- Information
- Copyright
- © Cambridge University Press 2015
References
1.Katz, A, Njuguna, E, Rakowsky, E, Sulkes, A, Sulkes, J, Fenig, E. Early development of vaginal shortening during radiation therapy for endometrial or cervical cancer. Int J Gynecol Cancer 2001; 11 (3): 234–235.CrossRefGoogle ScholarPubMed
2.Cox, J D, Stetz, J, Pajak, T F. Toxicity criteria of the Radio Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31 (5): 1341–1346.CrossRefGoogle Scholar
3.Brand, A H, Bull, C A, Cakir, B. Vaginal stenosis in patients treated with radiotherapy for carcinoma of the cervix. Int J Gynecol Cancer 2006; 16 (1): 288–293.CrossRefGoogle ScholarPubMed
4.Davidson, S E, Burns, M P, Routledge, J A, Swindell, R. The impact of radiotherapy for carcinoma of the cervix on sexual function assessed using the LENT SOMA scales. Radiother Oncol 2003; 68 (3): 241–247.Google Scholar
5.Gondi, V, Bentzen, S M, Sklenar, K Let al. Severe late toxicities following concomitant chemoradiotherapy compared to radiotherapy alone in cervical cancer: an inter-era analysis. Int J Radiat Oncol Biol Phys 2012; 84 (4): 973–982.CrossRefGoogle ScholarPubMed
6.Kirchheiner, K, Nout, R A, Tanderup, K, Lindegaard, J C, Westerveld, H, Haie-Meder, C, Petrič, P, Mahantshetty, U, Dörr, W, Pötter, R. Manifestation pattern of early-late vaginal morbidity after definitive radiation (chemo)therapy and image-guided adaptive brachytherapy for locally advanced cervical cancer: an analysis from the EMBRACE study. Int J Radiat Oncol Biol Phys 2014; 89 (1): 88–95.CrossRefGoogle ScholarPubMed
7.Haie-Meder, C, Pötter, R, Van Limbergen, Eet al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol 2005; 74 (3): 235–245.CrossRefGoogle Scholar