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Acute toxicity of 4-week versus 5-week hypofractionated radiotherapy in localised prostate cancer

Published online by Cambridge University Press:  14 April 2021

Mohammad Houshyari Open the ORCID record for Mohammad Houshyari [Opens in a new window] ,
Bahram Mofid ,
Maryam Alavi Tabatabaee ,
Mohsen Bakhshandeh Open the ORCID record for Mohsen Bakhshandeh [Opens in a new window]  and
Farzad Taghizadeh-Hesary Open the ORCID record for Farzad Taghizadeh-Hesary [Opens in a new window]
Mohammad Houshyari
Affiliation:
Department of Radiation Oncology, Shohada-e Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bahram Mofid
Affiliation:
Department of Radiation Oncology, Shohada-e Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Alavi Tabatabaee*
Affiliation:
Department of Radiation Oncology, Shohada-e Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohsen Bakhshandeh
Affiliation:
Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Farzad Taghizadeh-Hesary*
Affiliation:
Department of Radiation Oncology, Shohada-e Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Dr Maryam Alavi Tabatabaee, Department of Radiation-Oncology, Shohada-e Tajrish Hospital, Tehran, 19839-63113, Iran. Tel: +98 913 9110313. E-mail: maryam.alavi.taba@gmail.com; Dr Farzad Taghizadeh-Hesary, Department of Radiation-Oncology, Shohada-e Tajrish Hospital, Tehran, 19839-63113, Iran. Tel: +98 912 6086713. E-mail: f_taghizadeh@sbmu.ac.ir
Author for correspondence: Dr Maryam Alavi Tabatabaee, Department of Radiation-Oncology, Shohada-e Tajrish Hospital, Tehran, 19839-63113, Iran. Tel: +98 913 9110313. E-mail: maryam.alavi.taba@gmail.com; Dr Farzad Taghizadeh-Hesary, Department of Radiation-Oncology, Shohada-e Tajrish Hospital, Tehran, 19839-63113, Iran. Tel: +98 912 6086713. E-mail: f_taghizadeh@sbmu.ac.ir
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Abstract

Aim:

To compare the acute radiation-induced bowel and bladder toxicities of two hypofractionated radiotherapy (HFRT) regimens in localised prostate cancer (PCa).

Materials and methods:

This trial consists of patients with histologically confirmed stage T1-T3aN0M0 PCa, a prostate-specific antigen concentration of 40 ng/mL or lower, and Eastern Cooperative Oncology Group performance status of 0–2. Participants were randomly assigned (1:1) to 56 Gy in 16 fractions over 4 weeks (arm A) or 70·2 Gy in 26 fractions over 5 weeks (arm B). Acute bowel and bladder toxicities were assessed using Radiation Therapy Oncology Group criteria.

Results:

Between June 2018 and December 2019, 40 patients were randomly assigned to treatment with 4-week (n = 20) and 5-week HFRT (n = 20). In the third month after completion of radiotherapy, the cumulative incidence of acute bowel and bladder toxicities of arms A and B was 20 versus 5% and 70 versus 85%, respectively. The cumulative incidence of grade 2 or worse bowel and bladder toxicities of the 5-week regimen was non-inferior to 4-week HFRT [bowel toxicity: 5% (arm A) versus 5% (arm B), bladder toxicity: 50% (arm A) versus 60% (arm B), p = 0·52).

Findings:

The 5-week regimen of HFRT is non-inferior to 4-week HFRT in terms of acute bowel and bladder toxicities.

Keywords

acute toxicityandrogen suppressionhypofractionated radiotherapyintensity-modulated radiotherapyprostate cancer
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 4 , December 2022 , pp. 481 - 486
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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