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A case report of schizophrenia and HIV: HAART in association with clozapine

  • Sebastian Sanz-Cortés (a1), Elena Fashho-Rodriguez (a1), Tomás Sánchez-Araña Moreno (a1), Sergio Ruiz-Doblado (a2) and Jorge Marín-Martín (a3)...


The anti-psychotic drug management of patients with schizophrenia and HIV-1 infection is problematic. Such individuals are prone to extra-pyramidal reactions on account of HIV-1 induced sub-cortical involvement and exacerbation of cognitive impairment due to underlying CNS infection. Compliance with treatment can be problematic due to a disordered mental state and bone marrow toxicity may also result from the combined effects of anti-psychotic and retroviral agents. It is generally thought that atypical anti-psychotic drugs are the treatment of choice in such cases.

We present the case of a 30-year-old man with a history of schizophrenia who was successfully treated with clozapine following an admission to a psychiatric unit with acute confusional symptoms secondary to HIV-related central nervous system (CNS) involvement.


Corresponding author

Correspondence to: Dr Sergio Ruiz-Doblado, Servicio de Psiquiatría, Hospital de la Merced, Avda. Constitución, 2, 41640 Osuna (Sevilla), Spain. Tel & fax: +34 955 077257; E-mail:


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