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A case report of schizophrenia and HIV: HAART in association with clozapine

Published online by Cambridge University Press:  01 June 2009

Sebastian Sanz-Cortés ,
Elena Fashho-Rodriguez ,
Tomás Sánchez-Araña Moreno ,
Sergio Ruiz-Doblado  and
Jorge Marín-Martín
Sebastian Sanz-Cortés
Affiliation:
Hospital and Community Psychiatric Services, Osuna Hospital, Seville, Spain
Elena Fashho-Rodriguez
Affiliation:
Hospital and Community Psychiatric Services, Osuna Hospital, Seville, Spain
Tomás Sánchez-Araña Moreno
Affiliation:
Hospital and Community Psychiatric Services, Osuna Hospital, Seville, Spain
Sergio Ruiz-Doblado*
Affiliation:
Chairman, Psychiatric Department, Osuna Hospital
Jorge Marín-Martín
Affiliation:
Chairman, Internal Medicine Department, Osuna Hospital
*
Correspondence to: Dr Sergio Ruiz-Doblado, Servicio de Psiquiatría, Hospital de la Merced, Avda. Constitución, 2, 41640 Osuna (Sevilla), Spain. Tel & fax: +34 955 077257; E-mail: sergioruiz@ozu.es
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Abstract

The anti-psychotic drug management of patients with schizophrenia and HIV-1 infection is problematic. Such individuals are prone to extra-pyramidal reactions on account of HIV-1 induced sub-cortical involvement and exacerbation of cognitive impairment due to underlying CNS infection. Compliance with treatment can be problematic due to a disordered mental state and bone marrow toxicity may also result from the combined effects of anti-psychotic and retroviral agents. It is generally thought that atypical anti-psychotic drugs are the treatment of choice in such cases.

We present the case of a 30-year-old man with a history of schizophrenia who was successfully treated with clozapine following an admission to a psychiatric unit with acute confusional symptoms secondary to HIV-related central nervous system (CNS) involvement.

Keywords

SchizophreniaHIV-1clozapineCNSconfusionorganic psychiatry
Type
Case Report
Information
Journal of Psychiatric Intensive Care , Volume 5 , Issue 1 , June 2009 , pp. 47 - 49
Copyright
Copyright © NAPICU 2009

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