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On the Mechanisms of Convulsive Phenomena, with Reference to the Effects of Vasodilator Drugs

Published online by Cambridge University Press:  08 February 2018

D. J. Watterson
D. J. Watterson*
Affiliation:
Banstead Hospital (L.C.C.), Sutton, Surrey
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Extract

It is not known to what extent convulsions induced experimentally by various agencies are related pathogenetically to epileptic fits. There are, however, facts which suggest that the induced convulsions have, in their several mechanisms, points in common with one another and with epilepsy. Thus, caffeine and absinthe both cause convulsions in cats; when sub-convulsant doses of both are administered together convulsion ensues, suggesting that the two drugs operate on the same mechanism (Notkin and Pike, 1931). Insulin hypoglycæmia occasionally causes convulsions; it has been shown that during hypoglycæmia in man there is a lower fit-threshold to cardiazol (Georgi and Strauss, 1938), and in cats to thujone (Keith, 1935). The elicitation of convulsions by electrical stimulation of the cortex is facilitated by camphor monobromide, absinthe (Muskens, 1928), and cardiazol (Santha, 1939) on the one hand, and in epileptics as opposed to non-epileptics, on the other (Pen-field, 1936). Hydration has been shown to play a part in the precipitation of convulsions due to hypoglycæmia (Drabkin and Ravdin, 1937), thujone (Keith, 1935), and epilepsy (Fay, 1929; MacQuarrie, 1929).

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 85 , Issue 358 , September 1939 , pp. 904 - 931
Copyright
Copyright © Royal College of Psychiatrists, 1939 

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References

References

Comroe, J. H., and Starr, J.—Journ. Pharmacol., 1933, xlix, p. 283.Google Scholar
Coombes, H. C., and Pike, F. H.—Amer. Journ. Physiol., 1931, xcvii, p. 92.Google Scholar
Dautrebande, L., and Maréchal, R.—Comptes Rend de Soc. Biol., 1933, ii, p. 76.Google Scholar
Dennyssen, J. A. F., and Watterson, D. J.—Journ. Ment. Sci., 1938, lxxxiv, p. 1002.CrossRefGoogle Scholar
Dick, A., and McAdam, W.—Ibid., 1938, lxxxiv, p. 992.Google Scholar
Drabkin, D. L., and Ravdin, I. S.—Amer. Journ. Physiol., 1937, cxviii, p. 174.Google Scholar
Eichler, O., and Hildebrandt, F.—Arch. f. exp. Path. u. Pharmak., 1926, cxvi, p. 110.CrossRefGoogle Scholar
Fay, T.—Amer. Journ. Psychiat., 1929, viii, p. 783.CrossRefGoogle Scholar
Georgi, F., and Strauss, R.—Amer. Journ. Psychiat., 1938, xciv, suppl., p. 76.CrossRefGoogle Scholar
Hildebrandt, F., and Mugge, H.—Handbuch der exp. Pharmakol., 1937, v.Google Scholar
Keith, H. M.—Arch. of Neur. and Psychiat., 1935, xxxiii, p. 353.CrossRefGoogle Scholar
Keith, H. M. and Stravaky, G. W.—Ibid., 1935, xxxiv, p. 1022.Google Scholar
Kennedy, A.—Journ. Ment. Sci., 1937, lxxxiii, p. 609.Google Scholar
Low, A. B., Blaurock, M. F., Sachs, M., Wade, C., and Ross, E.—Arch. of Neur. and Psychiat., 1939, xli, p. 747.Google Scholar
Macdonald, M. E., and Cobb, S.—Journ. Neurol. Psychopath., 1923, iv, p. 228.Google Scholar
MacQuarrie, J.—Amer. Journ. Dis. Child., 1929, xxxviii, p. 401.Google Scholar
Meduna, L. v.—Amer. Journ. Psychiat., 1938, xciv, suppl., p. 48.Google Scholar
Muskens, L. J. J.—Epilepsy, London, 1928.Google Scholar
Notkin, J., and Pike, F. H.—Amer. Journ. Psychiat., 1931, x, p. 771.Google Scholar
Penfield, W.—Arch. of Neur. and Psychiat., 1936, xxxvi, p. 449.Google Scholar
Reitmann, F.—Psych.-Neur. Wochenschr., 1938, xvi, p. 5.Google Scholar
Sántha, K. v.—Arch. f. Psychiat. u. Nervenkr., 1939, cix, p. 128.CrossRefGoogle Scholar
Schmidt, C. F., and Hendrix, J. P.—The Circulation of the Brain and Spinal Cord, Baltimore, 1938, p. 229.Google Scholar
Schmitt, D.—Zeitschr.f. d. ges. Neur. u. Psychiat., 1939, clxvi, p. 108.Google Scholar
Uyematsu, S., and Cobb, S.—Arch. of Neur. and Psychiat., 1922, vii, p. 660.Google Scholar
Walk, A., and Mayer-Gross, W.—Journ. Ment. Sci., 1938, lxxxiv, p. 631.Google Scholar
Watterson, D. J., and Macdonald, R.—Ibid., 1939, lxxxv, p. 392.Google Scholar
von Braunmühl, A.—Zeitschr. f. d. ges Neur. u. Psychiat., 1938, clxi, p. 292.Google Scholar
Dreszer, R., and Scholz, W.—Ibid., 1938/39, clxiv, p. 140.Google Scholar
Foerster, O.—Deutsch. Zeitschr. f. Nervenheilkunde, 1926, xciv, p. 15.Google Scholar
Gibbs, F. A., Lennox, W. G., and Gibbs, E. L.—Arch. of Neur. and Psychiat., 1934, xxxii, P. 257.Google Scholar
Golla, F. L., Graham, S., and Walter, W. G.—Journ. Ment. Sci., 1937, lxxxiii, p. 137.Google Scholar
Hasenjager, T., and Spatz, H.—Arch. of Psychiat., 1937/38, cvii, p. 193.Google Scholar
Jefferson, G.—Arch. of Neur. and Psychiat., 1938, xl, p. 857.Google Scholar
Lennox, W. G.—Rev. Neurol., 1935, lxiv, p. 468.Google Scholar
Neubürger, K.—Tag. d. Deutsch. Ges. f. Kreislaufforschung, Tübingen, 1932, p. 136.Google Scholar
Opper, L.—Arch. of Neur. and Psychiat., 1939, xli, p. 460.CrossRefGoogle Scholar
Penfield, W.—Ibid., 1936, xxxvi, p. 449.Google Scholar
Pfeiffer, —Psych.-Neur. Wochenschr., 1938, xl, p. 474.Google Scholar
Pickworth, F. A.—Journ. Anat., London, 1934, lxix, p. 62.Google Scholar
Reitmann, F.—Psych.-Neur. Wochenschr., 1938, xl, pp. 51 and 391.Google Scholar
von Santha, Kalman.—Arch. f. Psychiat., 1939, cix, p. 128.Google Scholar
Scholz, W.—Zeitschr. f. d. ges Neur. u. Psychiat., 1933, cxlv, p. 471.CrossRefGoogle Scholar
Idem. —Allg. Zeitschr. f. Psychiat., 1936, civ, p. 589.Google Scholar
Idem. —In Bumke's Handbuch d. Psychiatrie, xi, p. 716, Julius Springer, Berlin, 1930.Google Scholar
Spielmeyer, W.—Zeitschr. f. d. ges Neur. u. Psychait., 1927, cix, p. 501.Google Scholar
Idem. —Ibid., 1933, cxlviii, p. 285.Google Scholar
Stauder, K. H.—Arch.f. Psychiat., 1934, cii, p. 547.Google Scholar
Strecker, E. A., Alpers, B. J., Flaherty, J. A., and Hughes, J.—Arch. of Neur. and Psychiat., 1939, xli, p. 996.Google Scholar
Tebelis, F.—Zeitschr. f. d. ges Neur. u. Psychiat., 1939, clxvi, p. 178.CrossRefGoogle Scholar
Wertham, F., and Wertham, F.—The Brain as an Organ, The Macmillan Co., New York, 1934.Google Scholar
von Braunmühl, A.—Zeitschr. f. d. ges Neur. u. Psychiat., 1938, clxi, p. 292.Google Scholar
Dreszer, R., and Scholz, W.—Ibid., 1938/39, clxiv, p. 140.Google Scholar
Foerster, O.—Deutsch. Zeitschr. f. Nervenheilkunde, 1926, xciv, p. 15.Google Scholar
Gibbs, F. A., Lennox, W. G., and Gibbs, E. L.—Arch. of Neur. and Psychiat., 1934, xxxii, P. 257.Google Scholar
Golla, F. L., Graham, S., and Walter, W. G.—Journ. Ment. Sci., 1937, lxxxiii, p. 137.Google Scholar
Hasenjager, T., and Spatz, H.—Arch. of Psychiat., 1937/38, cvii, p. 193.Google Scholar
Jefferson, G.—Arch. of Neur. and Psychiat., 1938, xl, p. 857.Google Scholar
Lennox, W. G.—Rev. Neurol., 1935, lxiv, p. 468.Google Scholar
Neubürger, K.—Tag. d. Deutsch. Ges. f. Kreislaufforschung, Tübingen, 1932, p. 136.Google Scholar
Opper, L.—Arch. of Neur. and Psychiat., 1939, xli, p. 460.CrossRefGoogle Scholar
Penfield, W.—Ibid., 1936, xxxvi, p. 449.Google Scholar
Pfeiffer, —Psych.-Neur. Wochenschr., 1938, xl, p. 474.Google Scholar
Pickworth, F. A.—Journ. Anat., London, 1934, lxix, p. 62.Google Scholar
Reitmann, F.—Psych.-Neur. Wochenschr., 1938, xl, pp. 51 and 391.Google Scholar
von Santha, Kalman.—Arch. f. Psychiat., 1939, cix, p. 128.Google Scholar
Scholz, W.—Zeitschr. f. d. ges Neur. u. Psychiat., 1933, cxlv, p. 471.CrossRefGoogle Scholar
Idem. —Allg. Zeitschr. f. Psychiat., 1936, civ, p. 589.Google Scholar
Idem. —In Bumke's Handbuch d. Psychiatrie, xi, p. 716, Julius Springer, Berlin, 1930.Google Scholar
Spielmeyer, W.—Zeitschr. f. d. ges Neur. u. Psychait., 1927, cix, p. 501.Google Scholar
Idem. —Ibid., 1933, cxlviii, p. 285.Google Scholar
Stauder, K. H.—Arch.f. Psychiat., 1934, cii, p. 547.Google Scholar
Strecker, E. A., Alpers, B. J., Flaherty, J. A., and Hughes, J.—Arch. of Neur. and Psychiat., 1939, xli, p. 996.Google Scholar
Tebelis, F.—Zeitschr. f. d. ges Neur. u. Psychiat., 1939, clxvi, p. 178.CrossRefGoogle Scholar
Wertham, F., and Wertham, F.—The Brain as an Organ, The Macmillan Co., New York, 1934.Google Scholar
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