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Uniaxial and biaxial mechanical behavior of human amnion

Published online by Cambridge University Press:  03 March 2011

Michelle L. Oyen ,
Robert F. Cook ,
Triantafyllos Stylianopoulos ,
Victor H. Barocas ,
Steven E. Calvin  and
Daniel V. Landers
Michelle L. Oyen*
Affiliation:
Department of Biophysical Sciences and Medical Physics, and Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota, Minneapolis, Minnesota 55455
Robert F. Cook
Affiliation:
Independent Consultant, Minneapolis, Minnesota 55413
Triantafyllos Stylianopoulos
Affiliation:
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455
Victor H. Barocas
Affiliation:
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455
Steven E. Calvin
Affiliation:
Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota,Minneapolis, Minnesota 55455; and Minnesota Perinatal Physicians/Allina Health System, Minneapolis, Minnesota 55407
Daniel V. Landers
Affiliation:
Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota, Minneapolis, Minnesota 55455
*
a)Address all correspondence to this author. Present address: University of Virginia, Center for Applied Biomechanics, 1011 Linden Ave., Charlottesville, VA 22902. e-mail: mloyen@virginia.edu This paper was selected as the Outstanding Meeting Paper for the 2004 MRS Fall Meeting Symposium Y Proceedings, Vol. 844.
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Abstract

Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly understood. The structural component of chorioamnion is the amnion sublayer, which provides the membrane’s mechanical integrity via a dense collagen network and is the focus of this investigation. Amnion uniaxial and planar equi-biaxial tension testing was performed using cyclic loading and stress-relaxation. Cyclic testing demonstrated dramatic energy dissipation in the first cycle followed by less hysteresis on subsequent cycles. Fractional energy dissipation per cycle was strain dependent, with greatest dissipation at small strain levels. Stress-relaxation testing demonstrated a level-dependent response and continued relaxation after long relaxation times. A nonlinear viscoelastic (separable) hereditary integral approach was inadequate to model the amnion response due to intrinsic coupling of the strain- and time-dependent responses.

Keywords

BiologicalMechanical propertiesMicrostructure
Type
Outstanding Meeting Paper
Information
Journal of Materials Research , Volume 20 , Issue 11 , November 2005 , pp. 2902 - 2909
Copyright
Copyright © Materials Research Society 2005

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References

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