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Preparation of controlled release nanodrug ibuprofen supported on mesoporous silica using supercritical carbon dioxide

Published online by Cambridge University Press:  28 September 2012

Min Ni ,
Qin-Qin Xu  and
Jian-Zhong Yin
Min Ni
Affiliation:
State Key Laboratory of Fine Chemicals, School of Chemical Machinery, Dalian, University of Technology, Dalian 116023, China
Qin-Qin Xu
Affiliation:
State Key Laboratory of Fine Chemicals, School of Chemical Machinery, Dalian, University of Technology, Dalian 116023, China
Jian-Zhong Yin*
Affiliation:
State Key Laboratory of Fine Chemicals, School of Chemical Machinery, Dalian, University of Technology, Dalian 116023, China
*
a)Address all correspondence to this author. e-mail: jzyin@dlut.edu.cn
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Abstract

Deposition of ibuprofen (IBU) into ordered mesoporous silica SBA-15 was carried out to prepare controlled release nanodrug using supercritical carbon dioxide (scCO2) as solvent at 17 MPa and 310.15 K. The maximum drug loading of IBU/SBA-15 was as high as 41.96%. The characterization of the obtained materials was performed using x-ray diffractometry (XRD), scanning electron microscopy (SEM), and nitrogen (N2) adsorption-desorption isotherms; the results indicate that most adsorbed drugs were inside the nanoscale channels. The in vitro study shows that the time of complete (100%) release significantly decreases as drug-loading decreases. The interesting aspect is that the samples with similar drug loading display different release rates, which may be due to differences in the drug quantity adsorbed inside the pores. In addition, the modified Noyes-Whitney equation was used to model the release kinetics for all the samples and a good agreement was obtained between the model representation and experimental data. In addition, the solubility of IBU in scCO2was tested through a high-pressure view cell at the temperature range of 298.15–320.15 K and pressure range of 7–17 MPa. The experimental solubility data were well correlated using Chrastil’s equation as well as Mendez-Santiago and Teja’s equation.

Keywords

controlled release drugibuprofenSBA-15solubilitysupercritical fluid depositionrelease kinetics
Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 22 , 22 November 2012 , pp. 2902 - 2910
Copyright
Copyright © Materials Research Society 2012

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