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Luminogen-functionalized mesoporous SBA-15 for fluorescent detection of antibiotic cefalexin

  • Lei Liu (a1), Xinyu Fu (a1), Hongliang Zhang (a1), Weiqing Ma (a1), Lili Zhang (a1), Yixin Zhang (a1), Meng Liu (a1), Kehan Liang (a1), Senlin Hou (a2) and Aibing Chen (a1)...


A novel luminogen-functionalized SBA-15, denoted as SNT, was developed by incorporating tris(4-bromophenyl)amine (TBPA) into SBA-15 via a “fixation-induced emission” strategy. The emission of TBPA on the matrix of SBA-15 was greatly enhanced, making the SNT possible as a fluorescence sensor. Cefalexin, a typical antibiotic, was chosen as the model analyte to be assayed and sensitive detection performance was achieved. This is the first time for cefalexin to be detected by a fluorescent method. Moreover, the SNT can be recycled by simply washing with proper solvents then used for next detection. This work provides a strategy to greatly improve the emission characteristics of fluorophores, even if a mediocre small fluorophore. It can be extended to design practical fluorescent sensors with high performance and recyclability by this strategy.


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1.Wright, G.D.: Solving the antibiotic crisis. ACS Infect. Dis. 1, 80 (2015).
2.Tremblay, J.F.: Spotlight grows on antibiotic pollution. C&EN Global Enterp. 95, 18 (2017).
3.Gothwal, R. and Shashidhar, T.: Antibiotic pollution in the environment: A review. Clean.–Soil, Air, Water 43, 479 (2015).
4.Li, W.H., Gao, L.H., Shi, Y.L., Liu, J., and Cai, Y.: Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China. Environ. Sci.: Processes Impacts 17, 1611 (2015).
5.Lan, L.Y., Yao, Y., Ping, J.F., and Ying, Y.B.: Recent advances in nanomaterial-based biosensors for antibiotics detection. Biosens. Bioelectron. 91, 504 (2017).
6.Yang, Y., Yin, S., Li, Y.X., Lu, D., Zhang, J., and Sun, C.J.: Application of aptamers in detection and chromatographic purification of antibiotics in different matrices. TrAC Trends Anal. Chem. 95, 1 (2017).
7.Zhou, L.Y., Gan, N., Zhou, Y., Li, T.H., Cao, Y.T., and Chen, Y.J.: A label-free and universal platform for antibiotics detection based on microchip electrophoresis using aptamer probe. Talanta 167, 544 (2017).
8.Wang, Z.H., Beier, R.C., and Shen, J.Z.: Immunoassays for the detection of macrocyclic lactones in food matrices—A review. Trac. Trends Anal. Chem. 92, 42 (2017).
9.Wang, Y.F., Zhang, T.B., and Liang, X.J.: Aggregation-induced emission: Lighting up cells, revealing life. Small 12, 6451 (2016).
10.Wang, H., Zhao, E.G., Lam, J.W.Y., and Tang, B.Z.: AIE luminogens: Emission brightened by aggregation. Mater. Today 18, 365 (2015).
11.Hong, Y.N., Lam, J.W.Y., and Tang, B.Z.: Aggregation-induced emission. Chem. Soc. Rev. 40, 5361 (2011).
12.Luo, J.D., Xie, Z.L., Lam, J.W.Y., Cheng, L., Chen, H., Qiu, C., Kwok, H.S., Zhan, X., Liu, Y., Zhu, D., and Tang, B.Z.: Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem. Commun. 18, 1740 (2001).
13.Shi, H.P., Xin, D.H., Gu, X.G., Zhang, P.F., Peng, H.R., Chen, S.M., Lin, G.W., Zhao, Z.J., and Tang, B.Z.: The synthesis of novel AIE emitters with the triphenylethene-carbazole skeleton and para-/meta-substituted arylboron groups and their application in efficient non-doped OLEDs. J. Mater. Chem. C 4, 1228 (2016).
14.Gong, S.W., Liu, Q.S., Wang, X.Q., Xia, B., Liu, Z.P., and He, W.J.: AIE-active organoboron complexes with highly efficient solid-state luminescence and their application as gas sensitive materials. Dalton Trans. 44, 14063 (2015).
15.Zhang, X.Y., Wang, K., Liu, M.Y., Zhang, X.Q., Tao, L., Chen, Y.W., and Wei, Y.: Polymeric AIE-based nanoprobes for biomedical applications: Recent advances and perspectives. Nanoscale 7, 11486 (2015).
16.Wang, Y., Arandiyan, H., Scott, J., Bagheri, A., Dai, H.X., and Amal, R.: Recent advances in ordered meso/macroporous metal oxides for heterogeneous catalysis: A review. J. Mater. Chem. A 5, 8825 (2017).
17.Zhang, X.Y., Zhang, X.Q., Wang, S.Q., Liu, M., Zhang, Y., Tao, L., and Wei, Y.: Facile incorporation of aggregation-induced emission materials into mesoporous silica nanoparticles for intracellular imaging and cancer therapy. ACS Appl. Mater. Interfaces 5, 1943 (2013).
18.Hu, Z.C., Deibert, B.J., and Li, J.: Luminescent metal-organic frameworks for chemical sensing and explosive detection. Chem. Soc. Rev. 43, 5815 (2014).
19.Wei, J., Sun, Z.K., Luo, W., Li, Y., Elzatahry, A.A., Al-Enizi, A.M., Deng, Y., and Zhao, D.: New insight into the synthesis of large-pore ordered mesoporous materials. J. Am. Chem. Soc. 139, 1706 (2017).
20.Li, D.D., Yu, J.H., and Xu, R.R.: Mesoporous silica functionalized with an AIE luminogen for drug delivery. Chem. Commun. 47, 11077 (2011).
21.Li, D.D., Liu, J.Z., Kwok, R.T.K., Liang, Z., Tang, B.Z., and Yu, J.H.: Supersensitive detection of explosives by recyclable AIE luminogen-functionalized mesoporous materials. Chem. Commun. 48, 7167 (2012).
22.Fan, Z.Y., Li, D.D., Yu, X., Zhang, Y.P., Cai, Y., Jin, J.J., and Yu, J.H.: AIE luminogen-functionalized hollow mesoporous silica nanospheres for drug delivery and cell imaging. Chem.–Eur. J. 22, 3681 (2016).
23.Miao, C.L., Li, D.D., Zhang, Y.P., Yu, J.H., and Xu, R.R.: AIE luminogen functionalized mesoporous silica nanoparticles as efficient fluorescent sensor for explosives detection in water. Microporous Mesoporous Mater. 196, 46 (2014).
24.Zhang, M., Feng, G.X., Song, Z.G., Zhou, Y-P., Chao, H-Y., Yuan, D.Q., Tristan, T.Y.T., Guo, Z.G., Hu, Z.G., Tang, B.Z., Liu, B., and Zhao, D.: Two-dimensional metal-organic framework with wide channels and eesponsive turn-on fluorescence for the chemical sensing of volatile organic compounds. J. Am. Chem. Soc. 136, 7241 (2014).
25.Wang, M., Zhang, G.X., Zhang, D.Q., Zhu, D., and Tang, B.Z.: Fluorescent bio/chemosensors based on silole and tetraphenylethene luminogens with aggregation-induced emission feature. J. Mater. Chem. 20, 1858 (2010).
26.Niamnont, N., Kimpitak, N., Wongravee, K., Rashatasakhon, P., Baldridge, K.K., Sieqel, J.S., and Sukwattanasinitt, M.: Tunable star-shaped triphenylamine fluorophores for fluorescence quenching detection and identification of nitro-aromatic explosives. Chem. Commun. 49, 780 (2013).
27.Zhang, X.Q., Zhang, X.Y., Tao, L., Chi, Z.G., Xu, J.R., and Wei, Y.: Aggregation induced emission-based fluorescent nanoparticles: Fabrication methodologies and biomedical applications. J. Mater. Chem. B 2, 4398 (2014).
28.Yan, L.L., Zhang, Y., Xu, B., and Tian, W.: Fluorescent nanoparticles based on AIE fluorogens for bioimaging. Nanoscale 8, 2471 (2016).
29.Shukla, S.K. and Quraishi, M.A.: Cefalexin drug: A new and efficient corrosion inhibitor for mild steel in hydrochloric acid solution. Mater. Chem. Phys. 120, 142 (2010).
30.Chong, A.S.M. and Zhao, X.S.: Functionalization of SBA-15 with APTES and characterization of functionalized materials. J. Phys. Chem. B 107, 12650 (2003).
31.Chen, A.B., Yu, Y.F., Wang, R.J., Yu, Y., Zhang, W., Tang, P., and Ma, D.: Nitrogen-doped dual mesoporous carbon for the selective oxidation of ethylbenzene. Nanoscale 7, 14684 (2015).
32.Deng, S.L., Chen, T.L., Chien, W.L., and Hong, J.L.: Aggregation-enhanced emission in fluorophores containing pyridine and triphenylamine terminals: Restricted molecular rotation and hydrogen-bond interaction. J. Mater. Chem. C 2, 651 (2014).
33.Zhao, D.Y., Sun, J.Y., Li, Q.Z., and Stucky, G.D.: Morphological control of highly ordered mesoporous silica SBA-15. Chem. Mater. 12, 275 (2000).
34.Marakatti, V.S. and Peter, S.C.: Nickel-antimony nanoparticles confined in SBA-15 as highly efficient catalysts for the hydrogenation of nitroarenes. New J. Chem. 40, 5448 (2016).
35.Thommes, M., Smarsly, B., Groenewolt, M., Ravikovitch, P.I., and Neimark, A.V.: Adsorption hysteresis of nitrogen and argon in pore networks and characterization of novel micro-and mesoporous silicas. Langmuir 22, 756 (2006).


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Luminogen-functionalized mesoporous SBA-15 for fluorescent detection of antibiotic cefalexin

  • Lei Liu (a1), Xinyu Fu (a1), Hongliang Zhang (a1), Weiqing Ma (a1), Lili Zhang (a1), Yixin Zhang (a1), Meng Liu (a1), Kehan Liang (a1), Senlin Hou (a2) and Aibing Chen (a1)...


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