Skip to main content Accessibility help
×
Home

Hollow Mesoporous Spheres with Cubic Pore Network as a Potential Carrier for Drug Storage and its In Vitro Release Kinetics

  • Yu-Fang Zhu (a1), Jian-Lin Shi (a1), Yong-Sheng Li (a1), Hang-Rong Chen (a1), Wei-Hua Shen (a1) and Xiao-Ping Dong (a1)...

Abstract

The hollow mesoporous spheres (HMS) with cubic pore network have been synthesized via a simple two-step method. Two drugs of different molecules size, Aspirin and Gentamicin, were tested by one simple adsorption process. Up to 336 mg Aspirin molecules can be stored in 1.0 g HMS, while Gentamicin molecules of much larger size are much more difficult to be introduced into the pore channels of HMS. The same results can be obtained by using MCM-48 and MCM-41 as comparative mesoporous carriers. The HMS shows significantly higher storage amount of Aspirin than conventional MCM-48 and MCM-41 due to its hollow core structure. The release process of HMS-Aspirin, MCM-48-Aspirin and MCM-41-Aspirin are found to have a sustained-release property and follow a Fickian diffusion mechanism. Moreover, the HMS is suitable for storage of drug molecules of much smaller size.

Copyright

Corresponding author

a)Address all correspondence to this author. e-mail: jlshi@sunm.shcnc.ac.cn

References

Hide All
1Kresge, C.T., Leonowicz, M.E., Roth, W.J., Vartuli, J.C. and Beck, J.S.: Ordered mesoporous molecular sieves synthesized by a liquid-crystal template. Nature 359, 710 (1992).
2Zhang, W.H., Lu, J., Han, B., Li, M., Xiu, J., Ying, P. and Li, C.: Direct synthesis and characterization of titanium-substituted mesoporous molecular sieve SBA-15. Chem. Mater. 14, 3413 (2002).
3Zhang, L.X., Zhang, W.H., Shi, J.L., Hua, Z.L., Li, Y.S. and Yan, J.N.: A new thioether functionalized organic-inorganic mesoporous composite as highly selective and capacious Hg2+ adsorbent. Chem. Commun. 2, 210 (2003).
4Yang, C., Sheu, H. and Chao, K.: Templated synthesis and structural study of densely packed metal nanostructures in MCM-41 and MCM-48. Adv. Funct. Mater. 12, 143 (2002).
5Tanev, P.T., Chibwe, M. and Pinnavaia, T.J.: Titanium-containing mesoporous molecular sieves for catalytic oxidation of aromatic compounds. Nature 368, 321 (1994).
6Schacht, S., Huo, Q., Voigt-Martin, I.G., Stucky, G.D. and Schuth, F.: Oil-water interface templating of mesoporous macroscale structures. Science 273, 768 (1996).
7Lin, H-P. and Mou, C-Y.: “Tubules-within-a-tubule” hierarchical order of mesoporous molecular sieves in MCM-41. Science 273, 765 (1996).
8Yang, P., Zhao, D., Chmelka, B.F. and Stucky, G.D.: Triblock-copolymer-directed syntheses of large-pore mesoporous silica fibers. Chem. Mater. 10, 2033 (1998).
9Huang, H., Remsen, E.E., Kowalewski, T. and Wooley, K.L.: Nanocages derived from shell cross-linked micelle templates. J. Am. Chem. Soc. 121, 3805 (1999).
10Lin, H-P., Cheng, Y-R. and Mou, C-Y.: Hierarchical order in hollow spheres of mesoporous silicates. Chem. Mater. 10, 3772 (1998).
11Zhu, G., Qiu, S., Terasaki, O. and Wei, Y.: Polystyrene bead-assisted self-assembly of microstructured silica hollow spheres in highly alkaline media. J. Am. Chem. Soc. 123, 7723 (2001).
12Li, W., Sha, X., Dong, W. and Wang, Z.: Synthesis of stable hollow silica microspheres with mesoporous shell in nonionic W/O emulsion. Chem. Commun. 20, 2434 (2002).
13Yu, C., Tian, B., Fan, J., Stucky, G.D. and Zhao, D.: Synthesis of siliceous hollow spheres with ultra large mesopore wall structures by reverse emulsion templating. Chem. Lett. 1, 62 (2002).
14Ottaviani, M.F., Mollo, L. and Fubini, B.: Use of nitroxides as topological monitors of the interaction of silica-based particles with components of the biological environment. J. Colloid Interface Sci. 191, 154 (1997).
15Vallet-Regí, M., Rámila, A., Real, R.P. del and Pérez-Pariente, J.: A new property of MCM-41: Drug delivery system. Chem. Mater. 13, 308 (2001).
16Hata, H., Saeki, S., Kimura, T., Sugahara, Y. and Kuroda, K.: Adsorption of taxol into ordered mesoporous silicas with various pore diameters. Chem. Mater. 11, 1110 (1999).
17Tourné-Péteilh, C., Lerner, D.A., Charnay, C., Nicole, L., Bégu, S. and Devoisselle, J-M.: The potential of ordered mesoporous silica for the storage of drugs: The example of a pentapeptide encapsulated in a MSU-Tween 80. Chem. Phys. Chem. 3, 281 (2003).
18Fisher, A.K., Huddersman, K.D. and Taylor, M.J.: Comparison of micro- and mesoporous inorganic materials in the uptake and release of the drug model fluorescein and its analogues. Eur. J. Chem. 9, 5873 (2003).
19Rámila, A., Muñoz, B., Pérez-Pariente, J. and Vallet-Regíi, M.: Mesoporous MCM-41 as drug host system. J. Sol-Gel Sci. Technol. 26, 1199 (2003).
20Muñoz, B., Rámila, A., Pérez-Pariente, J., Díaz, I. and Vallet-Regí, M.: MCM-41 organic modification as drug delivery rate regulator. Chem. Mater. 15, 500 (2003).
21Tourné-Péteilh, C., Brunel, D., Bégu, S., Chicle, B., Fajula, F., Lerner, D.A. and Devoisselle, J-M.: Synthesis and characterization of ibuprofen-anchored MCM-41 silica and silica gel. N. J. Chem. 27, 1415 (2003).
22Lai, C-Y., Trewyn, B.G., Jeftinija, D.M., Jeftinija, K., Xu, S., Jeftinija, S. and Lin, V.S-Y.: A mesoporous silica nanosphere-based carrier system with chmically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug moleculed. J. Am. Chem. Soc. 125, 4451 (2003).
23Kortesuo, P., Ahola, M., Kangas, M., Kangasniemi, I., Yli-Urpo, A. and Kiesvaara, J.: In vitro evaluation of sol-gel processed spray dried silica gel microspheres as carrier in controlled drug delivery. Int. J. Pharm. 200, 223 (2000).
24Kursawe, M., Glaubitt, W. and Thierauf, A.: Biodegradable silica fibers from sols. J. Sol-Gel Sci. Technol. 13, 267 (1998).
25Czuryszkiewicz, T., Ahvenlammi, J., Kortesuo, P., Ahola, M., Kleitz, F., Jokinen, M., Linden, M. and Rosenholm, J.B.: Drug release from biodegradable silica fibers. J. Non-Cryst. Solids 306, 1 (2002).
26Li, Y., Shi, J., Hua, Z., Chen, H., Ruan, M. and Yan, D.: Hollow spheres of mesoporous aluminosilicate with a three-dimensional pore network and extraordinarily high hydrethermal stability. Nano Lett. 3, 609 (2003).
27Xu, J., Luan, Z., He, H., Zhou, W. and Kevan, L.: A reliable synthesis of cubic mesoporous MCM-48 molecular sieve. Chem. Mater. 10, 3690 (1998).
28Zhang, W-H., Shi, J-L., Wang, L-Z. and Yan, D-S.: Preparation and characterization of ZnO clusters inside mesoporous silica. Chem. Mater. 12, 1408 (2000).
29Andreopoulos, A.G., Hatzi, E. and Doxastakis, M.: Controlled release of salicylic acid from poly(D, L-lactide). J. Mater. Sci.: Mater. Med. 12, 233 (2001).
30Korsmeyer, R.W., Gurny, R., Doelker, E., Buri, P. and Peppas, N.A.: Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15, 25 (1983).
31Peppas, N.A.: Analysis of fickian and non-fickian drug release from polymers. Pharm. Acta Helv. 60, 110 (1985).
32Schliecker, G., Schmiddt, C., Fuchs, S., Ehinger, A., Sandow, J. and Kissel, T.: In vitro and in vivo correlation of buserelin release from biodegradable implants using statistical moment analysis. J. Controlled Release 94, 25 (2004).
33Kim, S.S., Zhang, W. and Pinnavaia, T.J.: Ultrastable mesostructured silica vesicles. Science 282, 1302 (1998).
34Horcajada, P., Rámila, A., Diaz, I., Pérez-Pariente, J. and Vallet-Regí, M.: Influence of pore size of MCM-41 matrices on drug delivery rate. Microporous Mesoporous Mater. 68, 105 (2004).
35Okumura, M., Tsubota, S., Iwamoto, M. and Haruta, M.: Chemical vapor deposition of gold nanoparticles on MCM-41 and their catalytic activities for the low-temperature oxidation of CO and of H2. Chem. Lett. 4, 315 (1998).
36Zhao, X.G., Shi, J.L., Hu, B., Zhang, L.X. and Hua, Z.L.: Confinement of Cd3P2 nanoparticles inside ordered pore channels in mesoporous silica. J. Mater. Chem. 13, 399 (2003).

Keywords

Hollow Mesoporous Spheres with Cubic Pore Network as a Potential Carrier for Drug Storage and its In Vitro Release Kinetics

  • Yu-Fang Zhu (a1), Jian-Lin Shi (a1), Yong-Sheng Li (a1), Hang-Rong Chen (a1), Wei-Hua Shen (a1) and Xiao-Ping Dong (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed