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Fabrication of hybrid composites based on biomineralization of phosphorylated poly(ethylene glycol) hydrogels

Published online by Cambridge University Press:  31 January 2011

Chan Woo Kim ,
Sung Eun Kim ,
Yong Woo Kim ,
Hong Jae Lee ,
Hyung Woo Choi ,
Jeong Ho Chang ,
Jinsub Choi ,
Kyung Ja Kim ,
Kwang Bo Shim  and
Young-Keun Jeong
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Chan Woo Kim
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea; and Department of Ceramic Engineering, Hanyang University, Seoul 133-791, Korea
Sung Eun Kim
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Yong Woo Kim
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Hong Jae Lee
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Hyung Woo Choi
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Jeong Ho Chang
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Jinsub Choi
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Kyung Ja Kim
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
Kwang Bo Shim
Affiliation:
Department of Ceramic Engineering, Hanyang University, Seoul 133-791, Korea
Young-Keun Jeong
Affiliation:
Hybrid Materials Solution National Core Research Center (NCRC), Pusan National University, Busan 609-735, Korea
Sang Cheon Lee*
Affiliation:
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea
*
a) Address all correspondence to this author. e-mail: sclee@kicet.re.kr
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Abstract

A novel route to organic-inorganic composites was described based on biomineralization of poly(ethylene glycol) (PEG)-based hydrogels. The 3-dimensional hydrogels were synthesized by radical crosslinking polymerization of poly(ethylene glycol fumarate) (PEGF) in the presence of ethylene glycol methacrylate phosphate (EGMP) as an apatite-nuclating monomer, acrylamide (AAm) as a composition-modulating comonomer, and potassium persulfate (PPS) as a radical initiator. We used the urea-mediated solution precipitation technique for biomineralization of hydrogels. The apatite grown on the surface and interior of the hydrogel was similar to biological apatites in the composition and crystalline structure. Powder x-ray diffraction (XRD) showed that the calcium phosphate crystalline platelets on hydrogels are preferentially aligned along the crystallographic c-axis direction. Inductively-coupled plasma mass spectroscopy (ICP-MS) analysis showed that the Ca/P molar ratio of apatites grown on the hydrogel template was found to be 1.60, which is identical to that of natural bones. In vitro cell experiments showed that the cell adhesion/proliferation on the mineralized hydrogel was more pronounced than on the pure polymer hydrogel.

Keywords

BiomaterialCompositePolymer
Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 1 , January 2009 , pp. 50 - 57
Copyright
Copyright © Materials Research Society 2009

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