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Type II collagen autoimmunity and Ménière's disease

Published online by Cambridge University Press:  29 June 2007

R. C. D. Herdman ,
K. Morgan ,
P. J. L. Holt  and
R. T. Ramsden
R. C. D. Herdman*
Affiliation:
University Departments of Otolaryngology, Manchester
K. Morgan
Affiliation:
University Departments of Rheumatology, Manchester
P. J. L. Holt
Affiliation:
University Departments of Rheumatology, Manchester
R. T. Ramsden
Affiliation:
University Departments of Otolaryngology, Manchester
*
R. C. D. Herdman, F.R.C.S.,ENT Department, Royal Berkshire Hospital, London Road, Reading, Berkshire RG1 5AN
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Abstract

Antibodies to type II collagen have been reported by some authors to be raised in patients with Ménière's disease. In this study the antibody levels to type I and II collagen have been measured in 37 patients with Ménière's disease and 20 controls, using a solid-phase, double-antibody, enzyme-linked, immunoassay. No significant difference in antibody levels between the two groups was found. These findings do not support previously reported work which suggests that some cases of Ménière's disease are due to type II collagen autoimmunity.

Keywords

Ménière's diseaseCollagen, type II
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 11 , November 1993 , pp. 994 - 998
Copyright
Copyright © JLO (1984) Limited 1993

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