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Treatment and prognosis of nasopharyngeal angiofibroma involving the eye and optic nerve

  • Y Xu (a1), G Lin (a1), C Lin (a1), Z Fang (a2) (a3), Z Li (a4) (a3), A Zhou (a4) (a3), S Lan (a4) (a3), G Xu (a5) (a3) and Z Yi (a1)...



To discuss the minimally invasive treatment and prognosis of juvenile nasopharyngeal angiofibroma involving the eye and optic nerve.


Retrospective analysis of clinical data for 18 large juvenile nasopharyngeal angiofibromas, with reports of three typical cases.


The tumour invaded the orbit, eye, optic nerve and optic chiasm in 18, 9, 8 and 5 patients, respectively. Twelve patients were cured after surgery, with the affected eye and vision essentially returning to normal. In six patients, tumour residue was found in the middle cranial fossa; two of these six did not return for follow up. Four patients underwent radiotherapy; all four regained placement of the eye in a normal or near-normal position. One of these four patients regained normal visual acuity, two experienced no improvement in visual acuity, and one became blind.


In patients with this tumour, surgery may return the eye to the normal position and may restore visual acuity if the optic fundus, macula, retina and optic nerve are only mildly affected. Modern radiotherapy can treat the intracranial residue effectively. A combined approach via the antrum, infratemporal fossa and nasal cavity, using a Caldwell–Luc incision, provides minimally invasive surgical access.


Corresponding author

Address for correspondence: Dr Zixiang Yi, Department of ENT, First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China Fax: +86 591 87982780 E-mail:


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Treatment and prognosis of nasopharyngeal angiofibroma involving the eye and optic nerve

  • Y Xu (a1), G Lin (a1), C Lin (a1), Z Fang (a2) (a3), Z Li (a4) (a3), A Zhou (a4) (a3), S Lan (a4) (a3), G Xu (a5) (a3) and Z Yi (a1)...


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