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Systemic absorption of gentamicin ear drops

Published online by Cambridge University Press:  29 June 2007

K. M. J. Green ,
D. W. P. Lappin ,
J. W. A. Curley  and
J. P. de Carpentier
K. M. J. Green*
Affiliation:
Department of Otolaryngology, Royal Preston Hospital, Preston, UK.
D. W. P. Lappin
Affiliation:
Department of Renal Medicine, Royal Preston Hospital, Preston, UK.
J. W. A. Curley
Affiliation:
Department of Otolaryngology, Royal Preston Hospital, Preston, UK.
J. P. de Carpentier
Affiliation:
Department of Otolaryngology, Royal Preston Hospital, Preston, UK.
*
Address for correspondence: K. M. J. Green, 8 Albert Hill Street, Didsbury, Manchester M20 6RF
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Abstract

Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC™ occurred producing a serum gentamicin level of 6.2 μg/ml.

Keywords

Gentamicin, toxicityEar
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 10 , October 1997 , pp. 960 - 962
Copyright
Copyright © JLO (1984) Limited 1997

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References

Aronson, J. K., White, N. J. (1996) Principles of clinical pharmacology and during therapy. In Oxford Textbook of Medicine. 3rd Edition. (Weatherall, D. J., Ledingham, J. G. G., Warrell, D. A., eds.), Oxford University Press, Oxford, p 1261.Google Scholar
Ballantyne, J. C. (1970) Iatrogenic deafness. Journal of Laryngology and Otology 84: 967–1000.CrossRefGoogle ScholarPubMed
Black, F. O., Pesznecker, S. C. (1993) Vestibular ototoxicity: clinical considerations. Otolaryngologic Clinics of North America 26(5): 713–736.CrossRefGoogle ScholarPubMed
Brummett, R. E., Fox, K. E. (1989) Aminoglycoside-induced hearing loss in humans. Antimicrobial Agents and Chemotherapy 33: 797–800.CrossRefGoogle ScholarPubMed
Curtis, J. R., McDonald, S. J., Weston, J. H. (1967) Parenteral administration of gentamycin in renal failure: Patients undergoing intermittent haemodialysis. British Medical Journal 2: 537–539.CrossRefGoogle ScholarPubMed
Dijkmans, B. A. C., Mattie, H. (1987) Predictability of serum concentrations of aminoglycosides after haemodialysis. European Journal of Clinical Pharmacology 33: 179–183.CrossRefGoogle ScholarPubMed
Dumas, G., Bessord, G., Gavend, M., Cherachou, R. (1980) Risque de surdite pour installation de groubte auriculaires couteriant aminosides. Therapie 35: 357–363.Google Scholar
Esterhal, J. L., Bednar, J., Kimmelman, C. P. (1986) Gentamycin induced ototoxicity complicating treatment of chronic osteomyelitis. Clinical Orthopaedic Research 209: 186–188.Google Scholar
Fausti, S. A., Henry, J. A., Schaffer, H. I., Olson, D. J., Frey, R. H., McDonald, W. J. (1992) High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity. Journal of Infectious Diseases 165(6): 1026–1032.CrossRefGoogle ScholarPubMed
Federspil, P., Schahtzle, W., Tiesler, E. (1976) Pharmacokinetics ototoxicity of gentamycin, tobramycin and amikacin. Journal of Infectious Diseases 143(Suppl): 200–205.CrossRefGoogle Scholar
Halmagyi, G. M., Fattore, C. M., Curthoys, I. S., Wade, S. (1994) Gentamicin vestibulotoxicity. Otolaryngology - Head & Neck Surgery 111(5): 571–574.CrossRefGoogle ScholarPubMed
Hawkins, J. E., Johnson, L. G., Aran, J. M. (1967) Comparative tests of gentamycin toxicity. Journal of Infectious Diseases 199: 417–426.Google Scholar
Hewitt, W. L. (1973) Reflections of the clinical pharmacology of gentamycin. Acta Pathologica et Microbiologica Scandinavica 241(Suppl): 151–156.Google Scholar
Huizing, E. H., de Groot, J. C. M. J. (1987) Human cochlear pathology in aminoglycoside ototoxicity: A review. Acta Otolaryngologica 436(Suppl): 117–125.CrossRefGoogle ScholarPubMed
Jackson, G. G., Arcieri, G. (1971) Ototoxicity of gentamycin in man: a survey and controlled analysis of clinical experience in the United States. Journal of Infectious Diseases 124(Suppl): 5130–5137.CrossRefGoogle Scholar
Kahlmeter, G., Dahlager, J. (1984) Aminoglycoside toxicity and review of medical studies published between 1975 and 1982. Journal of Antimicrobial Chemotherapy 13a(Suppl): 9–22.CrossRefGoogle Scholar
Kellerhals, B. (1978) Horschaden durch ototoxische ohrtropfen. Ergebnisse Einer Umfrage. (Risk of inner ear damage from ototoxic drops). HNO (Berlin) 26(2): 49–52.Google Scholar
Kennet, R. H., Guess, M. G., Chole, R. A. (1983) Hyperthermia increase aminoglycoside ototoxicity. Acta Otolaryngologica 95: 323–327.Google Scholar
Lockwood, W. R., Bower, J. D. (1973) Tobramycin and gentamicin concentrations in the serum of normal and anephric patients. Antimicrobial Agents and Chemotherapy 3: 125–129.CrossRefGoogle ScholarPubMed
Matz, G. J. (1993) Aminoglycoside cochlear ototoxicity. Otolaryngologic Clinics of North America 26(5): 705–712.CrossRefGoogle ScholarPubMed
Moore, R. D., Smith, C. R. (1984) Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. Journal of Infectious Diseases 149: 23–30.CrossRefGoogle ScholarPubMed
Murphy, K. W. (1970) Deafness after topical neomycin. British Medical Journal 2: 114–117.CrossRefGoogle ScholarPubMed
Myers, R. M. (1970) Ototoxic effects of gentamycin. Archives of Otolaryngology 92: 160–162.CrossRefGoogle Scholar
Nakai, Y. (1977) Combined effect of 3′, 4′-di-deoxykanamycin B and potent diuretics on the cochlea. Laryngoscope 87: 1548–1558.CrossRefGoogle ScholarPubMed
Nomura, J. (1984) Otological significance of the round window. In Advances in Oto-Rhino-Laryngology (Pfoltz, C. R., ed.) Vol. 33, New York, S. Karger, pp. 1–162.Google Scholar
Podoshin, L., Fradis, M., David, B. (1989) Ototoxicity of ear drops in patients suffering from chronic otitis media. Journal of Laryngology and Otology 103: 46–50.CrossRefGoogle ScholarPubMed
Ramsden, R. T., Ackrill, P. (1982) Bobbing oscillopsia from gentamycin toxicity. British Journal of Audiology 16: 147–150.CrossRefGoogle Scholar
Sande, M. A., Mandell, G. L. (1980) Antimicrobial agents. In The Pharmacological Basis of Therapeutics. (Gilman, A. G., Goodman, L. S., Gilman, A., eds.), Macmillan Publishing Co., New York, pp. 1162–1180.Google Scholar
Solomons, N. B. (1992) Are antibiotic-containing ear drops toxic when applied to the middle ear? Health Trends 24(2): 64–65.Google Scholar
Tange, R. A., Dreschler, W. A., Van des Hulst, R. J. A. M. (1985) The importance of high-tone audiometry in ototoxicity monitoring. Archives of Otolaryngology 242: 77–81.Google Scholar
Tong, M. C. F., Woo, J. K. S., van Hasselt, C. A. (1996) A double-blind study of ofloxacin otic drops versus neomycinpolymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. Journal of Laryngology and Otology 110: 309–314.CrossRefGoogle ScholarPubMed
Tran Ba Huy, P., Deffrennes, D. (1988) Aminoglycoside ototoxicity: influence of dosage regimen of drug uptake and correlation between membrane binding and some clinical features. Acta Otolaryngologica 105(5–6): 511–515.CrossRefGoogle ScholarPubMed
Tran Ba Huy, P., Meulemans, A., Sterkers, O., Wassef, M., Amiel, C. (1983) Ethacrynic acid facilitates gentamycin entry into endolymph of rat. Hearing Research 11: 191–202.Google ScholarPubMed
Voldrich, L. (1965) The kinetics of streptomycin, kanamycin and neomycin in the inner ear. Acta Otolaryngologica 66: 243.CrossRefGoogle Scholar
Wallner, L. J. (1949) The otologic effects of streptomycin therapy. Annals of Otology, Rhinology and Laryngology 58; 111–116.CrossRefGoogle ScholarPubMed
Weinstein, M. J., Oden, E. M., Zeman, W. V., Wagman, G. H. (1965) Antibiotic absorption after otitis administration in dogs. Antimicrobial Agents and Chemotherapy 5: 239–244.Google Scholar
Wersall, J., Bjorkroth, B., Flock, A., Lundquist, P. G. (1971) Sensory hair fusion in vestibular sensory cells after gentamycin exposure. Archive fur klinische und experimentelle Ohren-Nasen und Kehlkopfheilkunde 200: 1–14.CrossRefGoogle ScholarPubMed