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Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

  • J Y Soh (a1), M Thalayasingam (a2), S Ong (a3), E X L Loo (a4), L P Shek (a1) and S S Chao (a3)...
  • Please note a correction has been issued for this article.

Abstract

Background:

Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy with Blomia tropicalis has not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years.

Methods:

A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively.

Results:

Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy.

Conclusion:

Sublingual immunotherapy with house dust mite extracts, including B tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

Copyright

Corresponding author

Address for correspondence: Dr Lynette Pei-Chi Shek, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore119228 E-mail: lynette_shek@nuhs.edu.sg

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A correction has been issued for this article: