Hostname: page-component-7479d7b7d-fwgfc Total loading time: 0 Render date: 2024-07-10T16:25:10.887Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies on the production of middle-ear effusion in the experimental animal

Published online by Cambridge University Press:  29 June 2007

Jamsheed A. Khan  and
John C. Campbell
Jamsheed A. Khan
Affiliation:
Glasgow
John C. Campbell
Affiliation:
Glasgow
Get access Rights & Permissions [Opens in a new window]

Abstract

Middle-ear effusions have been produced following eustachian tube obstruction in guinea pigs. This was achieved by plugging the pharyngeal orifice of the tube by an atraumatic lateral transpalatal incision. General anaesthesia was used throughout the entire procedure. The presence of fluid in the middle-ear cavity was determined by observing:

(a) The appearance of pallor of the drum.

(b) Retraction of the tympanic membrance.

(c) Cloudiness of the tympanic bullae on radiographs obtained at weekly intervals, confirmed by:

(d) Subsequent myringotomy.

Serial smears of the induced effusions showed an absence of chronic inflammatory cells except in the case of one animal which developed bacterial otitis media. The presence of secretory cells was demonstrated in the actual epithelial layer and lamina propria but no discrete glands were found. Squamous metaplasia of the lining of the middle-ear cleft was noted. The fluid from the tympanic cavity appeared watery, faintly turbid and non-mucoid, and resembled the serious type of effusion found in man.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 95 , Issue 10 , October 1981 , pp. 987 - 993
Copyright
Copyright © JLO (1984) Limited 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Friedmann, I. (1955) Journal of Laryngology and Otology, 69, 558–601.Google Scholar
Friedmann, I. (1963) Proceedings of the Royal Society of Medicine, 56, 695–699.CrossRefGoogle Scholar
Hentzer, E. (1972) Acta Otolaryngologica, 73, 394–401.CrossRefGoogle Scholar
Hilding, A. C. (1957) New England Journal of Medicine, 256, 634.CrossRefGoogle Scholar
Holmgren, L. (1940) Acta Otolaryngologica (Stockholm), 28, 587.Google Scholar
Hussl, B., and Lim, D. J. (1969) Archives of Otolaryngology, 89, 691–699.CrossRefGoogle Scholar
Kaneko, Y., Hiraide, F., and Paparella, M. M. (1971) Acta Otolaryngologica, 72, 85–92.CrossRefGoogle Scholar
Kaneko, Y., and Paparella, M. M. (1971) Acta Otolaryngologica, 72, 206–214.CrossRefGoogle Scholar
Kuijpers, W., Beek, Van Der J. M. H., and Willart, E. C. T. (1979) Acta Otolaryngologica, 87, 345–352.CrossRefGoogle Scholar
Lim, D. J., Paparella, M. M., and Kimura, R. S. (1967) Acta Otolaryngologica, 63, 425–444.CrossRefGoogle Scholar
Lim, D. J., and Hussl, B. (1970) Archives of Otolaryngology, 91, 585–593.CrossRefGoogle Scholar
Lim, D. J., and Birck, H. (1971) Annals of Otology, Rhinology and laryngology, 80, 838–853.CrossRefGoogle Scholar
Proud, G. O., and Odoi, H. (1970) Annals of Otology, Rhinology and Laryngology, 79, 30–32.CrossRefGoogle Scholar
Reiner, C. E., and Pulec, J. L. (1969) Annals of Otology, Rhinology and Laryngology, 78, 880–887.CrossRefGoogle Scholar
Sadé, J. (1966) Archives of Otolaryngology, 84, 137–143.CrossRefGoogle Scholar
Sadé, J. (1966) Archives of Otolaryngology, 84, 297–305.CrossRefGoogle Scholar
Sala, O., and Stefani, D. G. (1963) Laryngoscope, 73, 320–329.CrossRefGoogle Scholar
Senturia, B. H., Carr, C. D., and Rosenblunt, B. (1961) Acta Otolaryngologica, 54, 383–392.CrossRefGoogle Scholar
Senturia, B. H., Carr, C. D., and Ahlvin, R. C. (1962) Annals of Otology, Rhinology and Laryngology, 71, 632–647.CrossRefGoogle Scholar