Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-26T22:37:08.966Z Has data issue: false hasContentIssue false

Short-term weight gain after adenotonsillectomy in children with obstructive sleep apnoea: systematic review

Published online by Cambridge University Press:  21 December 2015

M Van
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
I Khan
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
S S M Hussain*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
*
Address for correspondence: Professor S S Musheer Hussain, Department of Otorhinolaryngology, Head and Neck Surgery, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK E-mail: musheer.hussain@nhs.net

Abstract

Background:

Children with obstructive sleep apnoea commonly undergo adenotonsillectomy as first-line surgical treatment. This paper aimed to investigate whether this intervention was associated with weight gain after surgery in the paediatric population with obstructive sleep apnoea.

Method:

Two independent researchers systematically reviewed the literature from 1995 to 2014 for studies on patients who underwent adenotonsillectomy with weight-based measurements before and after surgery. The databases used were Ovid Medline, Embase and PubMed.

Results:

Six papers satisfied all inclusion criteria. Four of these papers showed a significant weight increase and the others did not. The only high quality, randomised, controlled trial showed a significant increase of weight gain at seven months follow up, even in patients who were already overweight before their surgery.

Conclusion:

The current evidence points towards an association between adenotonsillectomy and weight gain in patients with obstructive sleep apnoea in the short term.

Type
Review Articles
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Presented orally at the ENT Scotland Annual Summer Meeting, 8 May 2015, Dunblane, Scotland, UK.

References

1American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med 1996;153:866–78CrossRefGoogle Scholar
2Brouillette, RT, Fernbach, SK, Hunt, CE. Obstructive sleep apnea in infants and children. J Pediatr 1982;100:3140CrossRefGoogle ScholarPubMed
3Bar, A, Tarasiuk, A, Segev, Y, Phillip, M, Tal, A. The effect of adenotonsillectomy on serum insulin-like growth factor-I and growth in children with obstructive sleep apnea syndrome. J Pediatr 1999;135:7680CrossRefGoogle ScholarPubMed
4Vontetsianos, HS, Davris, SE, Christopoulos, GD, Dacou-Voutetakis, C. Improved somatic growth following adenoidectomy and tonsillectomy in young children. Possible pathogenetic mechanisms. Hormones (Athens) 2005;4:4954CrossRefGoogle ScholarPubMed
5Jeyakumar, A, Fettman, N, Armbrecht, ES, Mitchell, R. A systematic review of adenotonsillectomy as a risk factor for childhood obesity. Otolaryngol Head Neck Surg 2011;144:154–8CrossRefGoogle ScholarPubMed
6Wang, Y, Lobstein, T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006;1:1125CrossRefGoogle ScholarPubMed
8Amin, R, Anthony, L, Somers, V, Fenchel, M, McConnell, K, Jefferies, J et al. Growth velocity predicts recurrence of sleep-disordered breathing 1 year after adenotonsillectomy. Am J Respir Crit Care Med 2008;177:654–9CrossRefGoogle ScholarPubMed
9Aydogan, M, Toprak, D, Hatun, S, Yuksel, A, Gokalp, AS. The effect of recurrent tonsillitis and adenotonsillectomy on growth in childhood. Int J Pediatr Otorhinolaryngol 2007;71:1737–42CrossRefGoogle ScholarPubMed
10Conlon, BJ, Donnelly, MJ, McShane, DP. Tonsillitis, tonsillectomy and weight disturbance. Int J Pediatr Otorhinolaryngol 1997;42:1723CrossRefGoogle ScholarPubMed
11Czechowicz, JA, Chang, KW. Analysis of growth curves in children after adenotonsillectomy. JAMA Otolaryngol Head Neck Surg 2014;140:491–6CrossRefGoogle ScholarPubMed
12Hashemian, F, Farahani, F, Sanatkar, M. Changes in growth pattern after adenotonsillectomy in children under 12 years old. Acta Med Iran 2010;48:316–19Google Scholar
13Hsu, WC, Kang, KT, Weng, WC, Lee, PL. Impacts of body weight after surgery for obstructive sleep apnea in children. Int J Obes (Lond) 2013;37:527–31CrossRefGoogle ScholarPubMed
14Kiris, M, Muderris, T, Celebi, S, Cankaya, H, Bercin, S. Changes in serum IGF-1 and IGFBP-3 levels and growth in children following adenoidectomy, tonsillectomy or adenotonsillectomy. Int J Pediatr Otorhinolaryngol 2010;74:528–31CrossRefGoogle ScholarPubMed
15Nieminen, P, Lopponen, T, Tolonen, U, Lanning, P, Knip, M, Lopponen, H. Growth and biochemical markers of growth in children with snoring and obstructive sleep apnea. Pediatrics 2002;109:e55CrossRefGoogle ScholarPubMed
16Smith, DF, Vikani, AR, Benke, JR, Boss, EF, Ishman, SL. Weight gain after adenotonsillectomy is more common in young children. Otolaryngol Head Neck Surg 2013;148:488–93CrossRefGoogle ScholarPubMed
17Soultan, Z, Wadowski, S, Rao, M, Kravath, RE. Effect of treating obstructive sleep apnea by tonsillectomy and/or adenoidectomy on obesity in children. Arch Pediatr Adolesc Med 1999;153:33–7CrossRefGoogle ScholarPubMed
18Wijga, AH, Scholtens, S, Wieringa, MH, Kerkhof, M, Gerritsen, J, Brunekreef, B et al. Adenotonsillectomy and the development of overweight. Pediatrics 2009;123:1095–101CrossRefGoogle ScholarPubMed
19Katz, ES, Moore, RH, Rosen, CL, Mitchell, RB, Amin, R, Arens, R et al. Growth after adenotonsillectomy for obstructive sleep apnea: an RCT. Pediatrics 2014;134:282–9CrossRefGoogle ScholarPubMed
20Karalok, ZS, Akdag, M, Turhan, M, Uzun, G, Ozdem, S, Dinc, O et al. Leptin and ghrelin levels in children before and after adenoidectomy or adenotonsillectomy. Horm Res Paediatr 2014;81:20–4CrossRefGoogle ScholarPubMed
21Huang, YS, Guilleminault, C, Lee, LA, Lin, CH, Hwang, FM. Treatment outcomes of adenotonsillectomy for children with obstructive sleep apnea: a prospective longitudinal study. Sleep 2014;37:71–6CrossRefGoogle ScholarPubMed
22Jabbari Moghaddam, Y, Golzari, SE, Saboktakin, L, Seyedashrafi, MH, Sabermarouf, B, Gavgani, HA et al. Does adenotonsillectomy alter IGF-1 and ghrelin serum levels in children with adenotonsillar hypertrophy and failure to thrive? A prospective study. Int J Pediatr Otorhinolaryngol 2013;77:1541–4CrossRefGoogle ScholarPubMed
23Kang, JM, Auo, HJ, Yoo, YH, Cho, JH, Kim, BG. Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children. Int J Pediatr Otorhinolaryngol 2008;72:1065–9CrossRefGoogle ScholarPubMed
24Roemmich, JN, Barkley, JE, D'Andrea, L, Nikova, M, Rogol, AD, Carskadon, MA et al. Increases in overweight after adenotonsillectomy in overweight children with obstructive sleep-disordered breathing are associated with decreases in motor activity and hyperactivity. Pediatrics 2006;117:e2008CrossRefGoogle ScholarPubMed
25World Health Organization. Growth Reference data for 5-19 year olds (2007). In: http://www.who.int/growthref/en/ [10 November 2015]Google Scholar
26Bland, RM, Bulgarelli, S, Ventham, JC, Jackson, D, Reilly, JJ, Paton, JY. Total energy expenditure in children with obstructive sleep apnoea syndrome. Eur Respir J 2001;18:164–9CrossRefGoogle ScholarPubMed
27De Serres, LM, Derkay, C, Sie, K, Biavati, M, Jones, J, Tunkel, D et al. Impact of adenotonsillectomy on quality of life in children with obstructive sleep disorders. Arch Otolaryngol Head Neck Surg 2002;128:489–96CrossRefGoogle ScholarPubMed
28Mitchell, RB, Kelly, J, Call, E, Yao, N. Long-term changes in quality of life after surgery for pediatric obstructive sleep apnea. Arch Otolaryngol Head Neck Surg 2004;130:409–12CrossRefGoogle ScholarPubMed
29Saaresranta, T, Polo, O. Sleep-disordered breathing and hormones. Eur Respir J 2003;22:161–72CrossRefGoogle ScholarPubMed
30Issa, FG, Sullivan, CE. The immediate effects of nasal continuous positive airway pressure treatment on sleep pattern in patients with obstructive sleep apnea syndrome. Electroencephalogr Clin Neurophysiol 1986;63:1017CrossRefGoogle ScholarPubMed