Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-19T06:26:37.322Z Has data issue: false hasContentIssue false
  • English
  • Français

Second primary lung cancer following laryngeal cancer: retrospective study of incidence and multivariate analysis of risk factors in 209 patients

Published online by Cambridge University Press:  31 October 2019

M Adams ,
G Gray ,
A Kelly ,
F Toner  and
R Ullah
M Adams*
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
G Gray
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
A Kelly
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
F Toner
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
R Ullah
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
*
Author for correspondence: Mr Mark Adams, Department of Otolaryngology/Head and Neck Surgery, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK E-mail: Jadams08@qub.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To analyse the incidence of second primary lung cancer following treatment for laryngeal cancer and to identify risk factors for its development.

Method

Retrospective case series.

Results

The five-year actuarial incidence of second primary lung cancer was 8 per cent (1.6 per cent per year). This was associated with a very poor median survival of seven months following diagnosis. Supraglottic tumours were associated with an increased risk of second primary lung cancer compared to glottic tumours in both univariate (hazard ratio = 4.32, p = 0.005) and multivariate analyses (hazard ratio = 4.14, p = 0.03).

Conclusion

Second primary lung cancer occurs at a rate of 1.6 per cent per year following a diagnosis of laryngeal cancer, and this is associated in a statistically significant manner with supraglottic primary tumour. The recent National Lung Cancer Screening Trial suggests a survival advantage of 20 per cent at five years with annual screening using low-dose computed tomography scanning of the chest in a comparable cohort to ours. These findings have the potential to inform post-treatment surveillance protocols in the future.

Keywords

Laryngeal NeoplasmsLung NeoplasmsNeoplasms, Multiple PrimaryNeoplasms, Second PrimaryEarly Detection Of Cancer
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 11 , November 2019 , pp. 974 - 979
Copyright
Copyright © JLO (1984) Limited, 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Mr M Adams takes responsibility for the integrity of the content of the paper

References

1Sjögren, EV, Snijder, S, van Beekum, J, Baatenburg de Jong, RJB. Second malignant neoplasia in early (Tis-T2) glottic carcinoma. Head Neck 2006;28:501–7Google Scholar
2Makeieff, M, Mercante, G, Jouzdani, E, Garrel, R, Crampette, L, Guerrier, B. Supraglottic hemipharyngolaryngectomy for the treatment of T1 and T2 carcinomas of the laryngeal margin and pyriform sinus. Head Neck 2004;26:701–5Google Scholar
3Colosanto, JM, Haffty, BG, Wilson, LD. Evaluation of local recurrence and second malignancy in patients with T1 and T2 squamous cell carcinoma of the larynx. Cancer J 2004;10:61–6Google Scholar
4Brandsorp-Boesen, J, Falk, RS, Evensen, JF, Boysen, M, Brøndbo, K. Risk of recurrence in laryngeal cancer. PLoS One 2016;11:e01644068Google Scholar
5Paleri, V, Roland, N. Introduction to the United Kingdom National Multidisciplinary Guidelines for Head and Neck Cancer. J Laryngol Otol 2016;130(suppl 2):S3–4Google Scholar
6Baxi, SS, Pinheiro, LC, Patil, SM, Pfister, DG, Oeffinger, KC, Elkin, EB. Causes of death in long-term survivors of head and neck cancer. Cancer 2014;120:1507–13Google Scholar
7Milano, MT, Peterson, CR 3rd, Zhang, H, Singh, DP, Chen, Y. Second primary lung cancer after head and neck squamous cell cancer: population-based study of risk factors. Head Neck 2012;34:1782–8Google Scholar
8Chuang, SC, Scelo, G, Tonita, JM, Tamao, S, Jonasson, JG, Kliewer, EV et al. Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries. Int J Cancer 2008;123:2390–6Google Scholar
9Pagedar, NA, Jayawardena, A, Charlton, ME, Hoffman, HT. Second primary lung cancer after head and neck cancer: implications for screening computed tomography. Ann Otol Rhinol Laryngol 2015;124:765–9Google Scholar
10Jayaprakash, V, Cheng, C, Reid, M, Dexter, EU, Nwogu, CE, Hicks, W et al. Previous head and neck cancers portend poor prognoses in lung cancer patients. Ann Thorac Surg 2011;92:1056–61Google Scholar
11Dhooge, IJ, De Vos, M, Van Cauwenberge, PB. Multiple primary malignant tumours in patients with head and neck cancer: results of a prospective study and future perspectives. Laryngoscope 1998;108:250–6Google Scholar
12Koppe, MJ, Zoetmulder, FA, van Zandewijk, N, Hart, AA, Rutgers, EJ. The prognostic significance of a previous malignancy in operable non-small cell lung cancer. Lung Cancer 2001;32:47–53Google Scholar
13Cetinkaya, E, Veyseller, B, Yildirim, YS, Aksoy, F, Ozgül, MA, Gençoğlu, A. Value of autofluorescence bronchoscopy in patients with laryngeal cancer. J Laryngol Otol 2011;125:181–7Google Scholar
14Lee, P, de Bree, R, Brokx, HA, Leemans, CR, Postmus, PE, Sutedja, TG. Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy? Lung Cancer 2008;62:309–15Google Scholar
15Shah, SI, Applebaum, EL. Lung cancer after head and neck cancer: role of chest radiography. Laryngoscope 2000;110:2033–6Google Scholar
16Shimizu, N, Ando, A, Teramoto, S, Moritani, Y, Nishii, K. Outcome of patients with lung cancer detected via mass screening as compared to those presenting with symptoms. J Surg Oncol 1992;50:7–11Google Scholar
17Engelen, AM, Stalpers, LJ, Manni, JJ, Ruijs, JH, van Daal, WA. Yearly chest radiography in the early detection of lung cancer following laryngeal cancer. Eur Arch Otolaryngol 1992;249:364–9Google Scholar
18Henschke, CI, McCauley, DI, Yankelevitz, DF, Naidich, DP, McGuinness, G, Miettinen, OS et al. Early Lung Cancer Action Project: overall design and findings from baseline screening. Lancet 1999;354:99–105Google Scholar
19National Lung Screening Trial Research Team, Aberle, DR, Adams, AM, Berg, CD, Black, WC, Clapp, JD et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395–409Google Scholar
20National Comprehensive Cancer Network. Lung Cancer Screening. In: www.nccn.org/patients/guidelines/lung_screening [27 September 2019]Google Scholar
21Bishop, JA, Ogawa, T, Chang, X, Illei, PB, Gabrielson, E, Pai, SI et al. HPV analysis in distinguishing second primary tumours from lung metastases in patients with head and neck squamous cell carcinoma. Am J Surg Pathol 2012;36:142–8Google Scholar
22Geurts, TW, Balm, AJ, van Velthuysen, ML, van Tinteren, H, Burgers, JA, van Zandwijk, N. Survival after surgical resection of pulmonary metastases and second primary squamous cell lung carcinomas in head and neck cancer. Head Neck 2009;31:220–6Google Scholar
23Chen, MC, Huang, WC, Chan, CH, Chen, PT, Lee, KT. Impact of second primary esophageal or lung cancer on survival of patients with head and neck cancer. Oral Oncol 2010;46:249–54Google Scholar
24Dequanter, D, Shahla, M, Lardinois, I, Gilbert, O, Hanquet, O, Tragas, G et al. Second primary lung malignancy in head and neck cancer patients. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:11–13Google Scholar
25Silvestri, F, Bussani, R, Cosatti, C, Bosatra, A. High relative risk of a second pulmonary cancer in patients affected by laryngeal cancer: differences by specific site of occurrence and lung cancer histotype. Laryngoscope 1994;104:222–5Google Scholar
26Lin, K, Patel, SG, Chu, PY, Matsuo, JM, Singh, B, Wong, RJ et al. Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx. Head Neck 2005;27:1042–8Google Scholar
27Chu, PY, Chang, SY, Huang, JL, Tai, SK. Different patterns of second primary malignancy in patients with squamous cell carcinoma of the larynx and hypopharynx. Am J Otolaryngol 2010;31:168–74Google Scholar
28Gao, X, Fisher, SG, Mohideen, N, Emami, B. Second primary cancers in patients with laryngeal cancer: a population-based study. Int J Radiat Oncol Biol Phys 2003;56:427–35Google Scholar
29Jones, AS, Morar, P, Phillips, DE, Field, JK, Husbband, D, Helliwell, TR. Second primary tumours in patients with head and neck squamous cell carcinoma. Cancer 1995;75:1343–53Google Scholar
30van Smeden, M, de Groot, JA, Moons, KG, Collins, GS, Altman, DG, Eijkemans, MJ et al. No rationale for 1 variable per 10 events criterion for binary logistic regression analysis. BMC Med Res Methodol 2016;16:163Google Scholar