Skip to main content Accessibility help

Role of T-helper 17 cell related cytokines in laryngeal cancer

  • T K Muderris (a1), F Gul (a2), A Doblan (a3), M Ergin (a4) and T Muderris (a5)...



To explore the role of T-helper 17 cells and their cascade in the pathogenesis of laryngeal cancer.


Prospectively, 110 consecutive patients with a suspicious laryngeal lesion were evaluated for serum levels of T-helper 17 cell related interleukins, including interleukins 23, 17A and 22, determined by enzyme-linked immunosorbent assay. The patients were divided into 2 groups after pathological evaluation: 49 patients with malignancy and 61 with benign pathology. Associations between interleukin levels and malignancy were determined via correlation analyses.


Interleukin 17A and 22 levels were significantly higher in the malignancy group than the benign lesion group. Pearson correlation analysis showed that interleukins 17A and 22 acted in a cascade, but interleukin 23 did not. According to predictive values, interleukin 17A levels were 3.87 times and interleukin 22 levels were 1.09 times more likely to be associated with laryngeal cancer. The cut-off values for predicting laryngeal cancer were 3.55 pg/ml for interleukin 17A and 119.82 pg/ml for interleukin 22.


T-helper 17 cell related interleukins are potential biomarkers that may be helpful in diagnosing laryngeal cancer. Moreover, these data may support neutralisation of T-helper 17 cell related cytokine activity, which could be an attractive strategy for treating laryngeal cancer.


Corresponding author

Author for correspondence: Assistant Prof Fatih Gul, Department of Otorhinolaryngology, Head and Neck Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey E-mail: Fax: +90 3122 912 786


Hide All

Assistant Prof F Gul takes responsibility for the integrity of the content of the paper



Hide All
1National Cancer Institute. Cancer Statistics Factsheets: Laryngeal Cancer. In: [15 April 2018]
2Stämpfli, MR, Anderson, GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 2009;9:377–84
3Langowski, JL, Zhang, X, Wu, L, Mattson, JD, Chen, T, Smith, K et al. IL-23 promotes tumour incidence and growth. Nature 2006;442:461–5
4Grivennikov, SI, Wang, K, Mucida, D, Stewart, CA, Schnabl, B, Jauch, D et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 2012;491:254–8
5Li, J, Lau, G, Chen, L, Yuan, YF, Huang, J, Luk, JM et al. Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression. PLoS One 2012;7:e46264
6Schetter, AJ, Nguyen, GH, Bowman, ED. Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin Cancer Res 2009;15:5878–87
7Coussens, LM, Werb, Z. Inflammation and cancer. Nature 2002;420:860–7
8Mantovani, A, Allavena, P, Sica, A, Balkwill, F. Cancer-related inflammation. Nature 2008;454:436–44
9Balkwill, F, Mantovani, A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539–45
10Schwartsburd, PM. Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control. Cancer Metastasis Rev 2003;22:95102
11Philip, M, Rowley, DA, Schreiber, H. Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol 2004;14:433–9
12Seril, DN, Liao, J, Yang, GY, Yang, CS. Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 2003;24:353–62
13Macarthur, M, Hold, GL, El-Omar, EM. Inflammation and cancer. II. Role of chronic inflammation and cytokine polymorphisms in the pathogenesis of gastrointestinal malignancy. Am J Physiol Gastrointest Liver Physiol 2004;286:G51520
14Mayron, R, Grimwood, RE, Siegle, RJ, Camisa, C. Verrucous carcinoma arising in ulcerative lichen planus of the soles. J Dermatol Surg Oncol 1998;14:547–51
15Risch, HA, Howe, GR. Pelvic inflammatory disease and the risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 1995;4:447–51
16Karin, M, Cao, Y, Greten, FR, Li, ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301–10
17Wu, S, Rhee, KJ, Albesiano, E, Rabizadeh, S, Wu, X, Yen, HR et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 2009;15:1016–22
18Ji, Y, Zhang, W. Th17 cells: positive or negative role in tumor? Cancer Immunol Immunother 2010;59:979–87
19Mojtahedi, Z, Khademi, B, Erfani, N, Taregh, Y, Rafati, Z, Malekzadeh, M et al. Serum levels of interleukin-7 and interleukin-8 in head and neck squamous cell carcinoma. Indian J Cancer 2014;51:227–30
20Melinceanu, L, Lerescu, L, Tucureanu, C, Caras, I, Pitica, R, Sarafoleanu, C et al. Serum perioperative profile of cytokines in patients with squamous cell carcinoma of the larynx. J Otolaryngol Head Neck Surg 2011;40:143–50
21Eyigor, M, Eyigor, H, Osma, U, Yilmaz, MD, Erin, N, Selcuk, OT et al. Analysis of serum cytokine levels in larynx squamous cell carcinoma and dysplasia patients. Iran J Immunol 2014;11:259–68
22Melinceanu, L, Sarafoleanu, C, Lerescu, L, Tucureanu, C, Caraş, I, Salageanu, A. Impact of smoking on the immunological profile of patients with laryngeal carcinoma. J Med Life 2009;2:211–18


Role of T-helper 17 cell related cytokines in laryngeal cancer

  • T K Muderris (a1), F Gul (a2), A Doblan (a3), M Ergin (a4) and T Muderris (a5)...


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed