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Role of prophylactic antibiotics in surgery for advanced head and neck cancer

  • D. A. Tandon (a1), S. Bahadur (a1), H. C. Laldina (a1) and K. R. Sundaram (a1)


Four regimens of prophylactic antibiotics were utilized in 122 consecutive patients of stages III and IV carcinoma of the upper aero-digestive tract undergoing major resections in a randomized single-blind study. Ampicillin, gentamicin, cephalexin and metronidazole were used in different combinations for periods of 5 or 10 days. A cephalexin-metronidazole protocol for 10 days was associated with lowest post-operative infection rate. Oral-oropharyngeal resection and use of pectoralis major myocutaneous flap were the most important factors contributing to infection.


Corresponding author

D. A. Tandon, Department of Otolaryngology, All Indian Institute of Medical Sciences, New Delhi 110029, India.


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Becker, G. D., Parell, G. J., Busch, D. E, Finegold, S. M., Acquarelli, M. J., Citron, D. M. (1980) The non-value of pre-operative and intraoperative cultures in predicting bacteriology of subsequent wound infection in patients undergoing major head and neck surgery. Laryngoscope, 90: 19331940.
Brown, B. M, Johnson, J. T., Wagner, R. L. (1987) Etiological factors in head and neck wound infection. Laryngoscope, 98: 587590.
Chodak, G. W., Plant, M. E. (1977) Use of systemic antibiotics for prophylaxis in surgery. Archives of Surgery. 112: 326334.
Cummings, C. W., Johnson, J., Chung, C. K., Sagerman, R. (1977) Complications of laryngectomy and neck dissection following planned pre-operative radiotherapy. Annals of Otology, Rhinology and Laryngology, 86: 745750.
Fee, W. R., Glenn, M., Handen, C, Hopp, M. L. (1984) Prophylactic antibiotics in head and neck surgery. Laryngoscope, 94: 612614.
Finegold, S. M. (1980) Metronidazole. Annals of Internal Medicine, 93: 585587.
Johnson, J. T., Myers, E. N., Thearle, P. B. (1984) Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope, 94: 4651.
Kaiser, A. B. (1986) Antimicrobial prophylaxis in surgery. New England Journal of Medicine, 30: 315; 11291138.
Mantravadi, R. V, Skolnik, E. M., Applebaum, E. M. (1981) Complications of post-operative and pre-operative radiotherapy in head and neck cancers. Archives of Otolaryngology, 107: 690693.
Piccart, M, Dor, P., Klastersky, J. (1983) Antimicrobial prophylaxis of infections in head and neck surgery. Scandinavian Journal of Infectious Diseases, Suppl 39: 9296.
Polk, H. C., Mayor, J. F. (1969) Post-operative wound infections: a prospective study of determinant factors and prevention. Surgery, 66: 97103.
Robbins, K. T, Byers, R. M., Cole, R., Fainstein, V., Guilamondegui, O. M, Schantz, S. P., Weber, R. S., Wolf, P., Goepfert, H. (1988) Metronidazole prophylaxis in head and neck oncology. Laryngoscope, 98: 803806.
Rubin, J., Johnson, J. T, Wagner, R. L., Yu, V. L. (1988) Bacteriologic analysis of wound infection following major head and neck surgery. Archives of Otolaryngology, 114: 969972.
Sawyer, R. (1988) Clinical implications of metronidazole antianaerobic prophylaxis in major head and neck surgical practice. Ear, Nose and Throat Journal, 67: 655662.
Seagle, M. B., Duberstein, L. E., Gross, C. W, Fletcher, J. L., Mustafa, A. Q. (1978) Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery. Otolaryngology–Head and Neck Surgery, 86: 568572.


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Role of prophylactic antibiotics in surgery for advanced head and neck cancer

  • D. A. Tandon (a1), S. Bahadur (a1), H. C. Laldina (a1) and K. R. Sundaram (a1)


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