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Role of cyclins D1 and D3 in vestibular schwannoma

Published online by Cambridge University Press:  13 July 2015

J Jabbour ,
P Earls ,
N Biggs ,
G Gracie ,
P Fagan  and
R Bova
J Jabbour
Affiliation:
University of Notre Dame Australia School of Medicine, Sydney, New South Wales, Australia
P Earls
Affiliation:
Department of Anatomical Pathology, SydPath, Sydney, New South Wales, Australia
N Biggs
Affiliation:
Department of Otorhinolaryngology, St Vincent's Clinic, Sydney, New South Wales, Australia
G Gracie
Affiliation:
Department of Anatomical Pathology, SydPath, Sydney, New South Wales, Australia
P Fagan
Affiliation:
Department of Otorhinolaryngology, St Vincent's Clinic, Sydney, New South Wales, Australia
R Bova*
Affiliation:
University of Notre Dame Australia School of Medicine, Sydney, New South Wales, Australia Department of Otorhinolaryngology, St Vincent's Clinic, Sydney, New South Wales, Australia
*
Address for correspondence: Dr Ron Bova, St Vincent's Clinic, Suite 1003, 438 Victoria Street, Darlinghurst, Sydney 2010, Australia Fax: 61-2-8382-6091 E-mail: rbova@ozemail.com.au
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Abstract

Background:

Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.

Objective:

This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3 and Ki-67, in vestibular schwannoma patients separated into two age groups: ≤40 years or >40 years.

Method:

Immunohistochemical detection of cyclin D1, cyclin D3 and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.

Results:

The proliferation index of vestibular schwannomas was statistically higher in the ≤40 years age group compared to that in the >40 years age group (mean of 4.52 vs 3.27, respectively; p = 0.01). Overexpression of cyclin D1 and cyclin D3 was found in 68 per cent and 44 per cent of tumours, respectively.

Conclusion:

There was an increased Ki-67 proliferation index in the younger age group that appears to correlate with clinical behaviour. Vestibular schwannomas in both age groups show increased expression of cyclin D1 and cyclin D3.

Keywords

Acoustic NeuromaNeurofibromatosis 2Cyclin D1Cyclin D3Ki-67 AntigenAge Of Onset
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue S1 , January 2016 , pp. S2 - S10
Copyright
Copyright © JLO (1984) Limited 2015 

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