Skip to main content Accessibility help
×
Home

Racial disparities in papillary thyroid microcarcinoma survival

  • U C Megwalu (a1) and A T Saini (a2)

Abstract

Objective:

To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma.

Methods:

The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute.

Results:

Black patients had lower overall survival than other racial groups (p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2.59) after adjusting for sex, marital status, age, year of diagnosis, multifocal disease and type of surgery. A subset analysis of Black patients revealed no significant difference in overall survival for total thyroidectomy versus lobectomy (p = 0.15).

Conclusion:

Black race is a negative prognostic factor in thyroid cancer, which cannot be explained by advanced disease stage. Further research on mechanisms by which race affects survival is needed to reveal areas of opportunity for interventions aimed at reducing health disparities in cancer care.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Racial disparities in papillary thyroid microcarcinoma survival
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Racial disparities in papillary thyroid microcarcinoma survival
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Racial disparities in papillary thyroid microcarcinoma survival
      Available formats
      ×

Copyright

Corresponding author

Address for correspondence: Dr Uchechukwu C Megwalu, Department of Otolaryngology – Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305, USA Fax: +1 650 725 8502 E-mail: megwaluu@yahoo.com

References

Hide All
1 Kilfoy, BA, Zheng, T, Holford, TR, Han, X, Ward, MH, Sjodin, A et al. International patterns and trends in thyroid cancer incidence, 1973–2002. Cancer Causes Control 2009;20:525–31
2 Davies, L, Welch, HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 2006;295:2164–7
3 Davies, L, Welch, HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg 2014;140:317–22
4 Leenhardt, L, Grosclaude, P, Chérié-Challine, L; Thyroid Cancer Committee. Increased incidence of thyroid carcinoma in France: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid 2004;14:1056–60
5 Dean, DS, Hay, ID. Prognostic indicators in differentiated thyroid carcinoma. Cancer Control 2000;7:229–39
6 Shaha, AR. Implications of prognostic factors and risk groups in the management of differentiated thyroid cancer. Laryngoscope 2004;114:393402
7 Jonklaas, J, Nogueras-Gonzalez, G, Munsell, M, Litofsky, D, Ain, KB, Bigos, ST et al. ; National Thyroid Cancer Treatment Cooperative Study Group. The impact of age and gender on papillary thyroid cancer survival. J Clin Endocrinol Metab 2012;97:E878–87
8 Chen, AY, Halpern, M. Factors predictive of survival in advanced laryngeal cancer. Arch Otolaryngol Head Neck Surg 2007;133:1270–6
9 Shavers, VL, Harlan, LC, Winn, D, Davis, WW. Racial/ethnic patterns of care for cancers of the oral cavity, pharynx, larynx, sinuses, and salivary glands. Cancer Metastasis Rev 2003;22:2538
10 Olarte, LS, Megwalu, UC. The impact of demographic and socioeconomic factors on major salivary gland cancer survival. Otolaryngol Head Neck Surg 2014;150:991–8
11 de Graeff, A, de Leeuw, JR, Ros, WJ, Hordijk, GJ, Blijham, GH, Winnubst, JA. Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer. Eur J Cancer 2001;37:332–9
12 Harari, A, Li, N, Yeh, MW. Racial and socioeconomic disparities in presentation and outcomes of well-differentiated thyroid cancer. J Clin Endocrinol Metab 2014;99:133–41
13 Yu, XM, Wan, Y, Sippel, RS, Chen, H. Should all papillary thyroid microcarcinomas be aggressively treated? An analysis of 18,445 cases. Ann Surg 2011;254:653–60
14Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2011 Sub (1973–2009 varying) - Linked To County Attributes - Total U.S., 1969–2010 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released April 2012, based on the November 2011 submission
15 Moo-Young, TA, Panergo, J, Wang, CE, Patel, S, Duh, HY, Winchester, DJ et al. Variations in clinicopathologic characteristics of thyroid cancer among racial ethnic groups: analysis of a large public city hospital and the SEER database. Am J Surg 2013;206:632–40
16 Noureldine, SI, Abbas, A, Tufano, RP, Srivastav, S, Slakey, DP, Friedlander, P et al. The impact of surgical volume on racial disparity in thyroid and parathyroid surgery. Ann Surg Oncol 2014;21:2733–9
17 Murray, JE. Marital protection and marital selection: evidence from a historical-prospective sample of American men. Demography 2000;37:511–21
18 Manzoli, L, Villari, P, Pirone, GM, Boccia, A. Marital status and mortality in the elderly: a systematic review and meta-analysis. Soc Sci Med 2007;64:7794
19 Rendall, MS, Weden, MM, Favreault, MM, Waldron, H. The protective effect of marriage for survival: a review and update. Demography 2011;48:481506
20 Cooper, GS, Virnig, B, Klabunde, CN, Schussler, N, Freeman, J, Warren, JL. Use of SEER-Medicare data for measuring cancer surgery. Med Care 2002;40:IV-43–48

Keywords

Racial disparities in papillary thyroid microcarcinoma survival

  • U C Megwalu (a1) and A T Saini (a2)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed