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Prognostic role of epidermal growth factor-like domain 7 protein expression in laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  07 September 2011

J-J Li ,
X-M Yang ,
S-H Wang  and
Q-L Tang
J-J Li
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China
X-M Yang
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
S-H Wang
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
Q-L Tang*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China
*
Address for correspondence: Dr Qing-Lai Tang, Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, P R China Fax: +86 731 85533525 E-mail: tangqinglai@126.com
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Abstract

Objective:

This study aimed to retrospectively analyse the expression of epidermal growth factor-like domain 7 protein in cases of laryngeal squamous cell carcinoma.

Methods:

We studied 116 patients retrospectively. Expression of epidermal growth factor-like domain 7 protein was determined in tumour and nontumour tissue samples, by immunohistochemistry.

Results:

Expression levels were significantly increased in 94 cases. Increased expression levels correlated well with tumour stage (p = 0.001) and lymph node metastasis (p = 0.002). Log-rank survival testing showed a significant difference between patients with marked versus limited expression levels (p = 0.03). Multivariable Cox regression analysis showed that epidermal growth factor-like domain 7 protein expression level was an independent predictor of laryngeal squamous cell carcinoma prognosis.

Conclusion:

These findings provide evidence that increased epidermal growth factor-like domain 7 protein expression is associated with laryngeal squamous cell carcinoma stage, lymph node metastasis and poor survival. This suggests that this protein may be a potential marker for laryngeal squamous cell carcinoma.

Keywords

EGF-Like Domain 7Laryngeal NeoplasmsSquamous Cell CarcinomaPrognosisTumour Marker
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 11 , November 2011 , pp. 1152 - 1157
Copyright
Copyright © JLO (1984) Limited 2011

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