Skip to main content Accessibility help

Premalignant changes in nasal and sinus polyps: a retrospective 10 year study (1979–1988)

  • A. de la Cruzc Mera (a1), M. J. Sánchez López (a1), E. Merino Royo (a1) and L. Requena (a1)


One hundred and seventy cases of nasal and/or sinus polyps diagnosed in the Pathology Service of the Hospital Militar Central GOMEZ/ULLA of Madrid (Spain) between 1.9.79 and 1.9.88 are reviewed. In two cases areas of ‘carcinoma in situ’ in the epithelium covering the polyps were demonstrated. The literature is reviewed for reports of malignant transformation and dysplastic changes in nasal and sinusal polyps. We suggest that precancerous changes may ocassionally be noted in inflammatory lesions, a fact that pathologists should keep in mind.


Corresponding author

Capitan Medico D. Alberto del la Cruz Mera Servicio de Anatonia PatologicaHospital Militar Central “Gomez-Ulla”c/ Glorieta de Ejercito s/a28047, Madrid, Spain.


Hide All
Badib, A. O., Kurohara, S. S., Webster, J. H. (1969) Treatment of cancer of the nasal cavity. American Journal of Roentgenology, 106: 824830.
Barnes, L. (1985) Surgical pathology of the Head and Neck. Marcel Dekker Inc. New York.
Batsakis, J. G. (1979) Tumors of the Head and Neck. Williams and Wilkins, Baltimore.
Busutil, A. (1978) Dysplastic epithelial changes in nasal polyps. Annals of Otology, Rhinology and Laryngology, 87: 416420.
Hasegawa, M., Nasu, M., Suginchi, Y., Watanabe, I. (1988) Malignant transformation of nasal polyp. Archives of Otolaryngology-Head and Neck Surgery, 114: 336337.
Hyams, V. J. (1971) Papillomas of the nasal cavity and paranasal sinuses. A clinicopathologic study of 315 cases. Annals of Otology, Rhinology and Laryngology, 80: 192206.
Kindblom, L. G., Angerwall, L. (1984) Nasal polyps with atypical stroma cells: A pseudosarcomatous lesion. A light and electron microcopsic and immunohistochemical investigation with implication on the type and nature of the mesenchymal cells. Acta Pathologica, Microbiologica et Inmunologica Scandinavica, 92: 6572.
Klenoff, B. H., Goodman, M. L. (1977) Mesenchymal cell atypicality in inflammatory polyps. Journal of Laryngology and Otology, 91: 751756.
Lasser, A., Rothfeld, P. R., Shapiro, R. S. (1976) Epithelial papilloma and squamous cell carcinoma of the nasal cavity and paranasal sinuses. A clinicopathological study. Cancer, 38: 25032510.
Maran, A. G. D., Stell, P. M. (1981) Otorrinolaringologia clinica. Expaxs S. A. Barcelona (Spain), de la edicion original Clinical Otolaryngology, Blackwell Scientific publications England.
Perzin, K. M., Lefkowitch, J. H., Hui, R. M. (1981) Bilateral nasal squamous carcinoma arising in papillomatosis: Report of a case developing after chemotherapy for leukemia. Cancer, 48: 23752382.
Rubin, I. C. (1910) The pathologic diagnosis of incipient carcinoma of the uterus. American Journal of Obstetrics, 62: 668676.
Smith, C. J., Echevarria, R., McLelland, C. A. (1974) Pseudosarcomatous changes in antrochoanal polyps. Archives of Otolaryngology, 99: 228230.
Snyder, R. N., Perzin, K. H. (1972) Papillomatosis of nasal cavity and paranasal sinuses (inverted papilloma, squamous papilloma). A clinicopathologic study. Cancer, 30: 668690.

Premalignant changes in nasal and sinus polyps: a retrospective 10 year study (1979–1988)

  • A. de la Cruzc Mera (a1), M. J. Sánchez López (a1), E. Merino Royo (a1) and L. Requena (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed