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Polymorphic variants of MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genotypes and the risk of laryngeal cancer in a smoking population

Published online by Cambridge University Press:  30 September 2013

G Aynali ,
M Doğan ,
R Sütcü ,
Ö Yüksel ,
M Yariktaş ,
F Ünal ,
H Yasan ,
B Ceyhan  and
M Tüz
G Aynali*
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
M Doğan
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
R Sütcü
Affiliation:
Biochemistry Department, School of Medicine, Kâtip Çelebi University, İzmir, Turkey
Ö Yüksel
Affiliation:
Department of Biochemistry, School of Medicine, Süleyman Demirel University, Isparta
M Yariktaş
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
F Ünal
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
H Yasan
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
B Ceyhan
Affiliation:
Department of Biochemistry, School of Medicine, Süleyman Demirel University, Isparta
M Tüz
Affiliation:
Department of Ear, Nose and Throat – Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta
*
Address for correspondence: Dr Giray Aynali, Ear, Nose and Throat – Head and Neck Surgery Department, School of Medicine, Süleyman Demirel University, DoğuYerleşkesi, Çünür 32200 Isparta, Turkey Fax: +90 (246) 2371762 E-mail: giraynali@med.sdu.edu.tr
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Abstract

Objective:

To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population.

Patients and methods:

Single nucleotide polymorphisms were determined in DNA from the peripheral blood erythrocytes of 48 heavy smokers (25 patients with laryngeal cancer and 23 cancer-free controls), using polymerase chain reaction.

Results:

There were no significant differences in age, smoking duration or smoking intensity, comparing the two groups. The homozygous AA genotype of MnSOD Val16Ala was significantly more prevalent in the cancer group than the control group (92 vs 13 per cent, respectively), while the heterozygous AV genotype of MnSOD Val16Ala was more prevalent in the control group than the cancer group (87 vs 8 per cent, respectively) (p < 0.001). There were no significant differences between the cancer and control groups regarding GPx1 Pro198Leu or CAT-262 C < T polymorphisms.

Conclusion:

Polymorphism of the MnSOD Val16Ala gene may contribute to susceptibility to laryngeal cancer among smokers.

Keywords

Laryngeal CancerGenetic PolymorphismSmokingGPX1 Protein, HumanMn SODCatalase
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 10 , October 2013 , pp. 997 - 1000
Copyright
Copyright © JLO (1984) Limited 2013 

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