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Melatonin deficiency at tissue level: a possible aetiological factor in nasal polyposis

Published online by Cambridge University Press:  24 June 2019

E Senturk ,
Y S Yildirim ,
O Ozturan ,
S E K Tekkeli  and
M V Kiziltaş
E Senturk*
Affiliation:
Department of Otorhinolaryngology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey
Y S Yildirim
Affiliation:
Department of Otorhinolaryngology, Dogus University, Istanbul, Turkey
O Ozturan
Affiliation:
Department of Otorhinolaryngology, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey
S E K Tekkeli
Affiliation:
Department of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey
M V Kiziltaş
Affiliation:
Department of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Turkey
*
Author for correspondence: Dr Erol Senturk, Department of Otorhinolaryngology, Bezmialem Vakif University, Adnan Menderes Boulevard, Istanbul 34600, Turkey E-mail: erolsent@gmail.com
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Abstract

Objective

The aim of this study was to examine whether melatonin is involved in the pathogenesis of nasal polyposis.

Method

This study included 29 patients with nasal polyposis and undergoing functional endoscopic sinus surgery. As a control group, 26 patients who had been operated on for a deviated nasal septum and concha bullosa were enrolled. Samples were taken from the nasal polyp tissue and from the resected middle concha bullosa mucosa of the control group. Serum samples were taken from all patients.

Results

It was found that the tissue and serum melatonin levels in the nasal polyp group were significantly lower compared with the tissue and serum melatonin levels in the control group.

Conclusion

In nasal polyposis, the melatonin level in the serum and tissue is lower than in individuals without polyposis. This deficiency may play a role in the pathogenesis of nasal polyposis.

Keywords

Nasal PolypsNasal MucosaSinusitisMelatonin
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 7 , July 2019 , pp. 600 - 603
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr E Senturk takes responsibility for the integrity of the content of the paper

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