Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-25T03:31:54.329Z Has data issue: false hasContentIssue false
  • English
  • Français

Melanoma of the middle ear: initial presentation, Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography imaging and follow up

Published online by Cambridge University Press:  27 January 2011

M W Huellner ,
M Cousin ,
T Linder ,
J D Soyka ,
C Bussmann ,
L Eberle  and
K Strobel
M W Huellner*
Affiliation:
Department of Nuclear Medicine and Radiology, Cantonal Hospital Lucerne, Switzerland
M Cousin
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Cantonal Hospital Lucerne, Switzerland
T Linder
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Cantonal Hospital Lucerne, Switzerland
J D Soyka
Affiliation:
Department of Nuclear Medicine, University Hospital Zurich, Switzerland
C Bussmann
Affiliation:
Department of Pathology, Cantonal Hospital Lucerne, Switzerland
L Eberle
Affiliation:
ORL Center Brunnen, Hospitals of Schwyz and Einsiedeln, Switzerland
K Strobel
Affiliation:
Department of Nuclear Medicine and Radiology, Cantonal Hospital Lucerne, Switzerland Department of Nuclear Medicine, University Hospital Zurich, Switzerland
*
Address for correspondence: Dr Martin Huellner, Department of Nuclear Medicine and Radiology, Cantonal Hospital Lucerne, CH-6000 Lucerne, Switzerland Fax: +41 41 205 4689 E-mail: martin.huellner@ksl.ch
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

We present a rare case of primary mucosal melanoma of the middle ear imaged with 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT).

Method:

Clinical, radiological, intra-operative and histological findings are discussed.

Results:

An 88-year-old woman presented with intermittent otorrhoea of the left ear for several months. Otoscopy revealed a livid protrusion of the tympanic membrane. Melanoma was not suspected initially, but was established on transmembranous biopsy. Pre-operative 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography revealed a mass lesion in the left tympanic cavity with high fluoro-deoxyglucose uptake, as well as an ipsilateral intraparotid lymph node metastasis. The patient underwent surgical treatment. The diagnosis of melanoma was confirmed histologically.

Conclusion:

In this rare case, clinical, radiological and surgical findings led to the diagnosis of a primary mucosal melanoma of the middle ear.

Keywords

Melanoma, MucosalMiddle EarPET/CTFDG
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 5 , May 2011 , pp. 536 - 539
Copyright
Copyright © JLO (1984) Limited 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Markovic, SN, Erickson, LA, Rao, RD, Weenig, RH, Pockaj, BA, Bardia, A et al. Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc 2007;82:364–80CrossRefGoogle ScholarPubMed
2Goerres, GW, Stoeckli, SJ, von Schulthess, GK, Steinert, HC. FDG PET for mucosal malignant melanoma of the head and neck. Laryngoscope 2002;112:381–5CrossRefGoogle ScholarPubMed
3McKenna, EL Jr, Holmes, WF, Harwick, R. Primary melanoma of the middle ear. Laryngoscope 1984;94:1459–60CrossRefGoogle ScholarPubMed
4Sherman, IW, Swift, AC, Haqqani, MT. Primary mucosal malignant melanoma of the middle ear. J Laryngol Otol 1991;105:1061–4CrossRefGoogle ScholarPubMed
5Curry, JM, Kung, BC, Willcox, TO Jr.Malignant melanoma of the middle ear. Otolaryngol Head Neck Surg 2007;136:856–7CrossRefGoogle ScholarPubMed
6Uchida, M, Matsunami, T. Malignant amelanotic melanoma of the middle ear. Arch Otolaryngol Head Neck Surg 2001;127:1126–8CrossRefGoogle ScholarPubMed
7Patel, SG, Prasad, ML, Escrig, M, Singh, B, Shaha, AR, Kraus, DH et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:247–57CrossRefGoogle ScholarPubMed
8Bradley, PJ. Primary malignant mucosal melanoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg 2006;14:100–4Google ScholarPubMed
9Thompson, JF, Scolyer, RA, Kefford, RF. Cutaneous melanoma. Lancet 2005;365:687–701CrossRefGoogle ScholarPubMed
10Dhomen, N, Marais, R. BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am 2009;23:529–45, ixCrossRefGoogle ScholarPubMed
11Balch, CM, Soong, SJ, Atkins, MB, Buzaid, AC, Cascinelli, N, Coit, DG et al. An evidence-based staging system for cutaneous melanoma. CA Cancer J Clin 2004;54:131–49, 82–4CrossRefGoogle ScholarPubMed
12Amer, MH, Al-Sarraf, M, Vaitkevicius, VK. Clinical presentation, natural history and prognostic factors in advanced malignant melanoma. Surg Gynecol Obstet 1979;149:687–92Google ScholarPubMed
13Sampson, JH, Carter, JH Jr, Friedman, AH, Seigler, HF. Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma. J Neurosurg 1998;88:11–20CrossRefGoogle ScholarPubMed
14Budman, DR, Camacho, E, Wittes, RE. The current causes of death in patients with malignant melanoma. Eur J Cancer 1978;14:327–30CrossRefGoogle ScholarPubMed
15Balch, CM, Buzaid, AC, Soong, SJ, Atkins, MB, Cascinelli, N, Coit, DG et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001;19:3635–48CrossRefGoogle ScholarPubMed
16Friedman, KP, Wahl, RL. Clinical use of positron emission tomography in the management of cutaneous melanoma. Semin Nucl Med 2004;34:242–53CrossRefGoogle ScholarPubMed
17Reinhardt, MJ, Joe, AY, Jaeger, U, Huber, A, Matthies, A, Bucerius, J et al. Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients. J Clin Oncol 2006;24:1178–87CrossRefGoogle ScholarPubMed
18Krug, B, Crott, R, Lonneux, M, Baurain, JF, Pirson, AS, Vander Borght, T. Role of PET in the initial staging of cutaneous malignant melanoma: systematic review. Radiology 2008;249:836–44CrossRefGoogle ScholarPubMed