Skip to main content Accessibility help
×
Home

Longitudinal analysis of Voice Handicap Index in early glottic cancer patients treated with transoral laser microsurgery: age, gender, stage and time dependence

  • C Lane (a1), M Rigby (a1), R Hart (a1), J Trites (a1), E Levi (a1) and S M Taylor (a1)...

Abstract

Objectives

Transoral laser microsurgery is an increasingly common treatment modality for glottic carcinoma. This study aimed to determine the effect of age, gender, stage and time on voice-related quality of life using the Voice Handicap Index-10.

Methods

Primary early glottic carcinoma patients treated with transoral laser microsurgery were included in the study. Self-reported Voice Handicap Index testing was completed pre-operatively, three months post-operatively, and yearly at follow-up appointments.

Results

Voice Handicap Index improvement was found to be dependent on age and tumour stage, while no significant differences were found in Voice Handicap Index for gender. Voice Handicap Index score was significantly improved at 12 months and 24 months. Time versus Voice Handicap Index modelling revealed a preference for non-linear over linear regression.

Conclusion

Age and stage are important factors, as younger patients with more advanced tumours show greater voice improvement post-operatively. Patient's Voice Handicap Index is predicted to have 95 per cent of maximal improvement by 5.5 months post-operatively.

Copyright

Corresponding author

Author for correspondence: Dr Mark Taylor, QEII Health Sciences Centre, VG Site 3rd Floor, Dickson Building, 3044 5820 University Ave, Halifax, Nova Scotia B3H 1V7, Canada E-mail: smarktaylor@eastlink.ca Fax: +1 902 473 4016

Footnotes

Hide All

Dr M Taylor takes responsibility for the integrity of the content of the paper

Presented at the 70th Annual Meeting of the Canadian Society of Otolaryngology – Head and Neck Surgery, 11–14 June 2016, Charlottetown, Canada.

Footnotes

References

Hide All
1Canis, M, Ihler, F, Martin, A, Wolff, HA, Matthias, C, Steiner, W. Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery. Head Neck 2014;36:652–9
2Pfister, DG, Spencer, S, Brizel, DM, Burtness, B, Busse, PM, Caudell, JJ et al. Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology. J Natl Compr Canc Netw 2014;12:1454–87
3Egawa, S, Shimane, T, Akiyama, R, Ikenoya, Y, Uzuki, A, Sugimoto, A et al. Laryngeal cancer treatment outcomes in our department [in Japanese]. Gan To Kagaku Ryoho 2011;38:1301–5
4Chiesa Estomba, CM, Reinoso, FAB, Velasquez, AO, Fernandez, JLR, Conde, JLF, Hidalgo, CS. Transoral CO2 laser microsurgery outcomes for early glottic carcinomas T1-T2. Int Arch Otorhinolaryngol 2016;20:212–17
5Spielmann, PM, Majumdar, S, Morton, RP. Quality of life and functional outcomes in the management of early glottic carcinoma: a systematic review of studies comparing radiotherapy and transoral laser microsurgery. Clin Otolaryngol 2010;35:373–82
6Fink, DS, Sibley, H, Kunduk, M, Schexnaildre, M, Kakade, A, Sutton, C et al. Subjective and objective voice outcomes after transoral laser microsurgery for early glottic cancer. Laryngoscope 2016;126:405–7
7Lee, HS, Kim, JS, Kim, SW, Noh, WJ, Kim, YJ, Oh, D et al. Voice outcome according to surgical extent of transoral laser microsurgery for T1 glottic carcinoma. Laryngoscope 2016;126:2051–6
8Aaltonen, L-M, Rautiainen, N, Sellman, J, Saarilahti, K, Mäkitie, A, Rihkanen, H et al. Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy. Int J Radiat Oncol Biol Phys 2014;90:255–60
9Rydell, R, Schalén, L, Fex, S, Elner, A. Voice evaluation before and after laser excision vs. radiotherapy of T1A glottic carcinoma. Acta Otolaryngol 1995;115:560–5
10Mendelsohn, AH, Matar, N, Bachy, V, Lawson, G, Remacle, M. Longitudinal voice outcomes following advanced CO2 laser cordectomy for glottic cancer. J Voice 2015;29:772–5
11Chu, P-Y, Hsu, Y-B, Lee, T-L, Fu, S, Wang, L-M, Kao, Y-C. Longitudinal analysis of voice quality in patients with early glottic cancer after transoral laser microsurgery. Head Neck 2012;34:1294–8
12Greulich, MT, Parker, NP, Lee, P, Merati, AL, Misono, S. Voice outcomes following radiation versus laser microsurgery for T1 glottic carcinoma: systematic review and meta-analysis. Otolaryngol Head Neck Surg 2015;152:811–19
13Mau, T, Courey, MS. Influence of gender and injection site on vocal fold augmentation. Otolaryngol Head Neck Surg 2008;138:221–5
14Sardesai, MG, Merati, AL, Hu, A, Birkent, H. Impact of patient-related factors on the outcomes of office-based injection laryngoplasty. Laryngoscope 2016;126:1806–9
15Vilaseca, I, Huerta, P, Blanch, JL, Fernández-Planas, AM, Jiménez, C, Bernal-Sprekelsen, M. Voice quality after CO2 laser cordectomy--what can we really expect? Head Neck 2008;30:43–9
16Oswal, V, Remacle, M, Jovanvic, S, Zeitels, SM, Krespi, JP, Hopper, C, eds. Principles and Practice of Lasers in Otorhinolaryngology and Head and Neck Surgery, 2nd edn. Amsterdam: Kugler Publications, 2014
17Rosen, CA, Lee, AS, Osborne, J, Zullo, T, Murry, T. Development and validation of the voice handicap index-10. Laryngoscope 2004;114:1549–56
18Kachuri, L, De, P, Ellison, LF, Semenciw, R; Advisory Committee on Canadian Cancer Statistics. Cancer incidence, mortality and survival trends in Canada, 1970–2007. Chronic Dis Inj Can 2013;33:6980
19Xie, L, Semenciw, R, Mery, L. Cancer incidence in Canada: trends and projections (1983–2032). Health Promot Chronic Dis Prev Can 2015;35(suppl 1):2186
20Flint, PW, Haughey, BH, Lund, VJ, Niparko, JK, Richardson, MA, Robbins, KT et al. Cummings Otolaryngology – Head & Neck Surgery, 5th edn. Philadelphia: Mosby/Elsevier, 2010
21Kim, H, Kim, SD, Shim, YJ, Lee, SY, Sung, M-W, Kim, KH et al. Is there any age cutoff to treat elderly patients with head and neck cancer? Comparing with septuagenarians and octogenarians. J Korean Med Sci 2016;31:1300–6
22Veldhuis, D, Probst, G, Marek, A, Noack, V, Ural, A, Adamietz, I et al. Tumor site and disease stage as predictors of quality of life in head and neck cancer: a prospective study on patients treated with surgery or combined therapy with surgery and radiotherapy or radiochemotherapy. Eur Arch Otorhinolaryngol 2016;273:215–24
23Laraway, DC, Lakshmiah, R, Lowe, D, Roe, B, Rogers, SN. Quality of life in older people with oral cancer. Br J Oral Maxillofac Surg 2012;50:715–20
24Markou, K, Christoforidou, A, Karasmanis, I, Tsiropoulos, G, Triaridis, S, Constantinidis, I et al. Laryngeal cancer: epidemiological data from Νorthern Greece and review of the literature. Hippokratia 2013;17:313–18
25Lee, MT, Gibson, S, Hilari, K. Gender differences in health-related quality of life following total laryngectomy. Int J Lang Commun Disord 2010;45:287–94
26Mendenhall, WM, Werning, JW, Hinerman, RW, Amdur, RJ, Villaret, DB. Management of T1-T2 glottic carcinomas. Cancer 2004;100:1786–92
27Agrawal, N, Ha, PK. Management of early-stage laryngeal cancer. Otolaryngol Clin North Am 2008;41:757–69
28Sadoughi, B. Function preservation in laryngeal cancer. Otolaryngol Clin North Am 2015;48:xvxvii
29Delsupehe, KG, Zink, I, Lejaegere, M, Bastian, RW. Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg 1999;121:528–33
30Deuflhard, P, Weiser, M, Zachow, S. Mathematics in facial surgery. Notices of the AMS 2006;53:1012–16
31Maccarini, AR, Stacchini, M, Salsi, D, Padovani, D, Pieri, F, Casolino, D. Surgical rehabilitation of dysphagia after partial laryngectomy. Acta Otorhinolaryngol Ital 2007;27:294–8
32Melong, JC, Rigby, MH, Bullock, M, Hart, RD, Trites, JRB, Taylor, SM. Transoral laser microsurgery for the treatment of oropharyngeal cancer: the Dalhousie University experience. J Otolaryngol Head Neck Surg 2015;44:39
33Phillips, TJ, Sader, C, Brown, T, Bullock, M, Wilke, D, Trites, JRB et al. Transoral laser microsurgery versus radiation therapy for early glottic cancer in Canada: cost analysis. J Otolaryngol Head Neck Surg 2009;38:619–23
34Rigby, MH, Taylor, SM. Review of transoral laser microsurgery for cancer of the upper aerodigestive tract. J Otolaryngol Head Neck Surg 2011;40:113–21
35McNeil, ML, Wilke, DR, Taylor, SM. Patient preferences in early glottic cancer treatment. Ear Nose Throat J 2016;95:281–3

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed