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Linkage analysis and the tracking of susceptibility genes

Published online by Cambridge University Press:  29 June 2007

Kevin Stopps  and
Fiona Macdonald
Kevin Stopps*
Affiliation:
Molecular Genetics Laboratory, West Midlands Regional Genetics Service, Birmingham Women's Hospital, Edgbaston, Birmingham B15 2TG.
Fiona Macdonald*
Affiliation:
Molecular Genetics Laboratory, West Midlands Regional Genetics Service, Birmingham Women's Hospital, Edgbaston, Birmingham B15 2TG.
*
Address for correspondence:Molecular Genetics Laboratory, West Midlands Regional Genetics Service, Birmingham Women's Hospital, Metchley Park Road, Edgbaston, Birmingham B15 2TG.
Address for correspondence:Molecular Genetics Laboratory, West Midlands Regional Genetics Service, Birmingham Women's Hospital, Metchley Park Road, Edgbaston, Birmingham B15 2TG.
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Abstract

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Type
Molecular Biology Series
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 4 , April 1998 , pp. 323 - 330
Copyright
Copyright © JLO (1984) Limited 1998

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References

Ott, J. (1991) Analysis of Human Genetic Linkage. Revised Edition. John Hopkins University Press, Baltimore.Google Scholar
Strachan, T., Read, A. P. (1996) Human Molecular Genetics. Bios Scientific Publishers, Oxford.Google Scholar
Donis-Keller, H., Green, P., Helms, C., Cartinhour, S., Weiffenbach, B., Stephens, K., Keith, T. P., et al. (1987) A genetic linkage map of the human genome. Cell 51: 319–337.CrossRefGoogle ScholarPubMed
Gusella, J. F., Wexler, N. S., Conneally, P. M., Naylor, S. L., Anderson, M. A., Tanzi, R. E., Watkins, P. C., et al. (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306: 234–238.CrossRefGoogle ScholarPubMed
Lathrop, G. M., Lalouel, J. M., Julier, C., Ott, J. (1984) Strategies for multilocus linkage analysis in humans. Proceedings of the National Academy of Sciences. United States of America 81: 3443–3446.CrossRefGoogle ScholarPubMed
Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, A. P., Harshman, K., Tavtgian, S., Liu, Q., et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66–71.CrossRefGoogle Scholar
Murray, J. C., Buetow, K. H., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Manion, F., Quillen, J., et al. (1994) A comprehensive human linkage map with centi-morgan density. Co-operative Human Linkage Center (CHLC). Science 265: 2049–2054.CrossRefGoogle Scholar
Ott, J. (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. American Journal of Human Genetics 26: 588–597.Google ScholarPubMed
Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., et al. (1995) Identification of the breast cancer susceptibility gene BRCA2. Nature 378: 789–792.CrossRefGoogle ScholarPubMed