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Levels of substance P and IgE decapeptide in nasal polyp fluid and matching sera: a preliminary study

Published online by Cambridge University Press:  29 June 2007

A. Drake-Lee ,
V. Jones ,
I. Lewin ,
S. Nayyar ,
A. Wells  and
D. Stanworth
A. Drake-Lee*
Affiliation:
Department of Otolaryngology, Queen Elizabeth Hospital, Birmingham, UK.
V. Jones
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
I. Lewin
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
S. Nayyar
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
A. Wells
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
D. Stanworth
Affiliation:
Department of Allergy and Clinical Immunology. University of Birmingham, UK.
*
Address for correspondence: Mr A. Drake-Lee, Department of Otolaryngology, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH. Fax: 0121 627 2291
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Abstract

Sixteen unselected patients with nasal polyps had the levels of substance P and IgE decapeptide measured by ELISA in the oedema fluids and their matched sera. All 16 samples had low levels of substance P in their sera and had high level of substance P in eight samples of nasal polyp oedema. There was a considerable variation in the values of IgE decapeptide found in the sera but 14 polyp oedema fluids had high levels of IgE decapeptide. This study supports the idea that there is a linkage between the cellular and neurovascular responses. High levels of IgE decapeptide suggest that mast cell reactions occur in the majority of cases and that IgE may be implicated in the process of mast cell degranulation.

Keywords

Nasal polypsSubstance PIgE
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 3 , March 1996 , pp. 225 - 227
Copyright
Copyright © JLO (1984) Limited 1996

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References

Cauna, N., Hindover, K. H., Manzethi, G. W., Swanson, B. W. (1972) Fine structure of nasal polyps. Annals of Otolaryngology 81: 41–58.Google Scholar
Chaen, T., Wantanabe, N., Mogi, G., Mori, K., Takeyama, M. (1993) Substance P and vasoactive intestinal peptide in nasal secretions and plasma from patients with nasal allergy. Annals of Otology, Rhinology and Laryngology 102: 16–21.CrossRefGoogle ScholarPubMed
Drake-Lee, A. B., McLaughlan, P. (1982) Clinical symptoms, free histamine and IgE in patients with nasal polyps. International Archives of Allergy and Applied Immunology 69: 268–271.CrossRefGoogle Scholar
Drake-Lee, A. B., Lowe, D., Swanston, A., Grace, A. (1984) Clinical profile and recurrence of nasal polyps. Journal of Laryngology and Otology 98: 783–793.Google Scholar
Jung, T., Juhn, S., Hwang, D., Stewart, R. (1987) Prostaglandins, leukotrienes and other arachidonic acid metabolites in nasal polyps and nasal mucosa. Laryngoscope 97: 184–189.CrossRefGoogle ScholarPubMed
Nigam, S., Kunkel, G., Herold, D., Baumer, F., Jusuf, L. (1986) Nasal polyps and their content of arachidonic acid metabolites. New England and Region Allergy Proceedings 7: 109–112.Google Scholar
Petruson, B., Hansson, H. A., Petruson, K. (1988) Insulin-like growth factor 1 is a possible pathogenic mechanism in nasal polyps. Acta Otolaryngologica 106: 156–160.Google Scholar
Salari, H., Borgeat, P., Steffenrud, S., Richard, J., Bedard, P., Hebert, J., Pelletier, G. (1986) Immunological and non- immunological release of leukotrienes and histamine from human nasal polyps. Clinical and Experimental Immunology 63: 711–717.Google ScholarPubMed
Smith, D., Gerrard, J., White, J. (1987) Comparison of arachidonic acid metabolites in nasal polyps and eosinophils. International Archives of Allergy and Applied lmmunology 82: 83–88.Google Scholar
Stanworth, D. R. (1984) The role of non-antigenic receptors in mast cell signalling process. Molecular Immunology 21: 1183–1190.CrossRefGoogle Scholar
Stanworth, D., Jones, V., Lewin, I., Nayyar, S. (1990) Allergy treatment with a peptide vaccine. Lancet 336: 1279–1281.CrossRefGoogle ScholarPubMed
Udderman, R., Sundler, F. (1986) Innervation of the upper airways. Clinical Chest Medicine 7: 201–209.Google Scholar