Hostname: page-component-76fb5796d-45l2p Total loading time: 0 Render date: 2024-04-26T08:44:52.317Z Has data issue: false hasContentIssue false
  • English
  • Français

Laryngeal aspergillosis in an acquired immunodeficiency syndrome patient

Published online by Cambridge University Press:  29 June 2007

C. Delbrouck ,
G. Chantrain ,
S. Kampouridis  and
M. Petein
C. Delbrouck*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, C.H.U. Saint-Pierre, Belgium
G. Chantrain
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, C.H.U. Saint-Pierre, Belgium
S. Kampouridis
Affiliation:
Department of Radiology, C.H.U. Saint-Pierre, Belgium
M. Petein
Affiliation:
Department of Anatomopathology, Institut J. Bordet, Université Libre de Bruxelles, Belgium
*
Address for corresapondence: C. Delbrouck, Service d'ORL et de Chirurgie Cervico-faciale, CHU Saint-Pierre, 322, rue Haute, 1000 Bruxelles, Belgium
Get access Rights & Permissions [Opens in a new window]

Abstract

Aspergillosis is a rare infection. It varies considerably in its virulence depending on whether or not the patient affected is immunodepressed. The serious form is characterized by vascular invasion with haematogenic dissemination, tissue infarction andnecrosis. The most often affected site is the lung. A laryngeal localization is exceptional and usually results from dissemination from a lower airways portal of entry. Diagnosisis difficult: cultures are only positive in 50 per cent of cases, while in 60 per cent of cases the characteristic histological features reminiscent of sprigs of mistletoe are only found on postmortem examination. In view of the high morbidity and mortality in acquired immunodeficiency syndrome (AIDS) sufferers, this condition must be treated early and aggressively. Treatment is based essentially on amphotericin B and itraconazole.

Keywords

AspergillosisLarynxAcquired immunodeficiency syndrome
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 5 , May 1998 , pp. 488 - 490
Copyright
Copyright © JLO (1984) Limited 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benson-Mitchell, R., Tolley, N., Croft, C. B., Gallimore, A. (1994) Aspergillosis of the larynx. Journal of Laryngotogy and Otology 108(10): 883–885.CrossRefGoogle ScholarPubMed
Denning, D. W., Hostetler, J. S., Kauffmann, C. A., Galgiani, J. N., Sugar, A. M., Gallis, H., Dismukes, W. E. (1994) Niaid mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis. American Journal of Medicine 97: 135–144.CrossRefGoogle Scholar
Dupont, B., Lortholary, O. (1996) Infections fongiques. SIDA 1996 (Ed: Paris, Doin) pp 205–215.Google Scholar
Eloy, P., Watelet, J. B., Bertrand, B., Rombeaux, P.,Doyen, C., Delos, M., Trigaux, J. P. (1996) Aspergillose sinusienne invasive: état de Ia question et présentation d'un cas clinique. Cahiers d'ORL 31(8): 499–507.Google Scholar
Fisher, E. W., Richards, A., Anderson, G., Albert, D. M. (1992) Laryngeal candidiasis: a cause of airway obstruction in the immunocompromised child. Journal of Laryngology and Otology 106: 168–170.CrossRefGoogle ScholarPubMed
Hass, A., Hyatt, A. C., Kattan, M., Weiner, M. A., Hodes, D. S. (1987) Hoarseness in immunocompromised children: association with invasive fungal infection. Journal of Pediatrics 111(5): 731–733.Google Scholar
Kingdom, T. T., Lee, K. C. (1996) Invasive aspergillosis of the larynx in AIDS. Otolaryngology–Head and Neck Surgery 115(1): 135–137.CrossRefGoogle ScholarPubMed
Kuo, P., Lee, L. N., Yang, P. C., Chen, Y. C., Luh, K. T. (1996) Aspergillus laryngotracheobronchitis presenting as stridorin patient with peripheral T cell lymphoma. Thorax 51(8): 869–870.CrossRefGoogle ScholarPubMed
Loeuille, G. A., Berthou, C., Hilmarsdottir, I., Menard, O.. (1993) Aspergilloses traitées par l'itraconazole: analyses de 64 cas. Journal of Mycotogie Medicate 3: 1–13.Google Scholar
Richardson, B. E., Morrison, V. A., Gapany, M. (1996) Invasive aspergillosis of the larynx: case report and review of the literature. Otolaryngology–Head and Neck Surgery 114(3): 471–473.CrossRefGoogle ScholarPubMed
Rispail, P., Jarry, D. T., Tomas, C., Jarry, D. M. (1996) Mycoses sinusiennes. Cahiers d'ORL 31(8): 459–467.Google Scholar
Serrano, E., Percodani, J., Flores, P., Dilem, S., Pessey, J. J. (1996) Les aspergillomes sinusiens: à propos de 45 cas. Annales d'Otolaryngotogie et de Chirurgie Cervicofaciale 113: 86–91.Google Scholar
Stoll, D., Dumon, T. (1996) Les mycoses pseudotumorales. Cahiers d'ORL 31(8): 495–498.Google Scholar
Young, R. C., Bennett, J. E., Vogel, C. L., Carbone, P. P., DeVita, V. T. (1970) Aspergillosis: the spectrum of the diseasein 98 patients. Medicine 49: 147–173.CrossRefGoogle Scholar