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Immunohistochemical localisation of endothelin receptor subtypes in the cochlear lateral wall

Published online by Cambridge University Press:  08 June 2010

D-Y Xu ,
Q-X Zhang ,
Y-Q Ma ,
X-L Zheng  and
S-X Liu
D-Y Xu
Affiliation:
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
Q-X Zhang
Affiliation:
Department of Otorhinolaryngology, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Y-Q Ma
Affiliation:
Department of Histology and Embryology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
X-L Zheng
Affiliation:
Molecular and Translational Medicine Laboratory, The Second Affiliated Hospital of Sichuan University, Chengdu, China
S-X Liu*
Affiliation:
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China
*
Address for correspondence: Dr Shi-Xi Liu, Department of Otorhinolaryngology - Head & Neck Surgery, West China hospital, Sichuan University, Sichuan Chengdu 610041, China. E-mail: liusx999@163.com
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Abstract

Objective:

Endothelin has many biological activities, including regulation of the functions of the cochlear lateral wall. The present study aimed to analyse the expression of endothelin receptors in the cochlear lateral wall, and to investigate the significance of such receptors in maintaining the homeostatic environment of the cochlea.

Methods:

The cochleae of healthy guinea pigs were fixed, decalcified, embedded in paraffin and serially sectioned. Expression of the endothelin receptor subunits A and B in the cochlear lateral wall was examined using an immunohistochemical technique.

Results:

Different degrees of endothelin receptor subunit A and endothelin receptor subunit B like activity were found distributed in the cells of the cochlear lateral wall.

Conclusion:

These findings support the theory that endothelin, via its receptors, plays an important role in maintaining the homeostatic environment of the cochlea.

Keywords

EndothelinCochleaInner Ear
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 10 , October 2010 , pp. 1073 - 1077
Copyright
Copyright © JLO (1984) Limited 2010

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