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Immunohistochemical evaluation with Ki-67: An application to salivary gland tumours

Published online by Cambridge University Press:  29 June 2007

M. Murakami ,
I. Ohtani ,
H. Hojo  and
H. Wakasa
M. Murakami*
Affiliation:
Department of Otolaryngology, Fukushima Medical College, Fukushima, Japan.
I. Ohtani
Affiliation:
Department of Otolaryngology, Fukushima Medical College, Fukushima, Japan.
H. Hojo
Affiliation:
Department of Pathology, Fukushima Medical College, Fukushima, Japan.
H. Wakasa
Affiliation:
Department of Pathology, Fukushima Medical College, Fukushima, Japan.
*
Dr M. Murakami, M.D., Matsukichyo 1–23, Fukushima City, Fukushima 960, Japan.
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Abstract

Using Ki-67, a monoclonal antibody, the proliferating capacity of 15 salivary gland tumours, including nine pleomorphic adenomas, four adenoid cystic carcinomas, one mucoepidermoid carcinoma and one acinic cell carcinoma was determined immunohistochemically, using normal salivary gland tissue as a control. The frequency of Ki-67 positive cells was 4.7 per cent in the normal salivary gland and one per cent in pleomorphic adenomas, whereas the average frequency in malignant tumours was 18.3 per cent. Among adenoid cystic carcinomas, the frequency was related to the morphological type; the solid sub-type had the highest frequency of Ki-67-positive cells. As this sub-type is recognized as the most aggressive of these tumours, this technique has the potential of providing an early indication of the clinical behaviour of a tumour.

Keywords

ImmunohistochemistrySalivary gland neoplasms
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 1 , January 1992 , pp. 35 - 38
Copyright
Copyright © JLO (1984) Limited 1992

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